TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus

We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammation and myocytolysis with intracellular vacuolizati...

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Detalles Bibliográficos
Autores principales: Elshikha, Ahmed S., Teng, Xiang Yu, Kanda, Nathalie, Li, Wei, Choi, Seung-Chul, Abboud, Georges, Terrell, Morgan, Fredenburg, Kristianna, Morel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289616/
https://www.ncbi.nlm.nih.gov/pubmed/35860280
http://dx.doi.org/10.3389/fimmu.2022.914468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289616/
https://www.ncbi.nlm.nih.gov/pubmed/35860280
http://dx.doi.org/10.3389/fimmu.2022.914468

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