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TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus
We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammation and myocytolysis with intracellular vacuolizati...
Autores principales: | Elshikha, Ahmed S., Teng, Xiang Yu, Kanda, Nathalie, Li, Wei, Choi, Seung-Chul, Abboud, Georges, Terrell, Morgan, Fredenburg, Kristianna, Morel, Laurence |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289616/ https://www.ncbi.nlm.nih.gov/pubmed/35860280 http://dx.doi.org/10.3389/fimmu.2022.914468 |
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