Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease

A body temperature >38.3°C that lasts ≥3 weeks and lacks a clear diagnosis after 1 week of standard hospital examination and treatment is called “fever of unknown origin” (FUO). The main causes of FUO are infections, hematological diseases, autoimmune diseases, and other non-infectious inflammato...

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Autores principales: Dong, Yuxin, Gao, Yulei, Chai, Yanfen, Shou, Songtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289621/
https://www.ncbi.nlm.nih.gov/pubmed/35859749
http://dx.doi.org/10.3389/fmicb.2022.931058
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author Dong, Yuxin
Gao, Yulei
Chai, Yanfen
Shou, Songtao
author_facet Dong, Yuxin
Gao, Yulei
Chai, Yanfen
Shou, Songtao
author_sort Dong, Yuxin
collection PubMed
description A body temperature >38.3°C that lasts ≥3 weeks and lacks a clear diagnosis after 1 week of standard hospital examination and treatment is called “fever of unknown origin” (FUO). The main causes of FUO are infections, hematological diseases, autoimmune diseases, and other non-infectious inflammatory diseases. In recent years, quantitative metagenomics next-generation sequencing (Q-mNGS) has been used widely to detect pathogenic microorganisms, especially in the contribution of rare or new (e.g., severe acute respiratory syndrome-coronavirus-2) pathogens. This review addresses the undetermined cause of fever and its evaluation by Q-mNGS.
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spelling pubmed-92896212022-07-19 Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease Dong, Yuxin Gao, Yulei Chai, Yanfen Shou, Songtao Front Microbiol Microbiology A body temperature >38.3°C that lasts ≥3 weeks and lacks a clear diagnosis after 1 week of standard hospital examination and treatment is called “fever of unknown origin” (FUO). The main causes of FUO are infections, hematological diseases, autoimmune diseases, and other non-infectious inflammatory diseases. In recent years, quantitative metagenomics next-generation sequencing (Q-mNGS) has been used widely to detect pathogenic microorganisms, especially in the contribution of rare or new (e.g., severe acute respiratory syndrome-coronavirus-2) pathogens. This review addresses the undetermined cause of fever and its evaluation by Q-mNGS. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289621/ /pubmed/35859749 http://dx.doi.org/10.3389/fmicb.2022.931058 Text en Copyright © 2022 Dong, Gao, Chai and Shou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Dong, Yuxin
Gao, Yulei
Chai, Yanfen
Shou, Songtao
Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title_full Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title_fullStr Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title_full_unstemmed Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title_short Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease
title_sort use of quantitative metagenomics next-generation sequencing to confirm fever of unknown origin and infectious disease
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289621/
https://www.ncbi.nlm.nih.gov/pubmed/35859749
http://dx.doi.org/10.3389/fmicb.2022.931058
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