Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback

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The heart pumps blood into circulation against vascular resistance and actively regulates the contractile force to compensate for mechanical load changes. Our experimental data show that cardiomyocytes have a mechano-chemo-transduction (MCT) mechanism that increases intracellular [Formula: see text]...

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Detalles Bibliográficos
Autores principales: Kazemi-Lari, Mohammad A., Shimkunas, Rafael, Jian, Zhong, Hegyi, Bence, Izu, Leighton, Shaw, John A., Wineman, Alan S., Chen-Izu, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289640/
https://www.ncbi.nlm.nih.gov/pubmed/35860762
http://dx.doi.org/10.1016/j.isci.2022.104667

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