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Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy

Colorectal carcinoma represents a major cause of mortality and 0.2–12% of resected colonic polyps have malignant cells inside. We performed a retrospective study of patients with resected polyps during a period of 13 years. A total of 905 patients had 2033 polyps removed; 122 polyps (109 patients) h...

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Autores principales: Cazacu, Sergiu Marian, Săftoiu, Adrian, Iordache, Sevastiţa, Ghiluşi, Mirela-Corina, Georgescu, Claudia Valentina, Iovănescu, Vlad Florin, Neagoe, Carmen Daniela, Streba, Liliana, Caliţa, Mihaela, Burtea, Elena Daniela, Cârţu, Dan, Leru, Polliana Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289694/
https://www.ncbi.nlm.nih.gov/pubmed/35673811
http://dx.doi.org/10.47162/RJME.62.4.04
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author Cazacu, Sergiu Marian
Săftoiu, Adrian
Iordache, Sevastiţa
Ghiluşi, Mirela-Corina
Georgescu, Claudia Valentina
Iovănescu, Vlad Florin
Neagoe, Carmen Daniela
Streba, Liliana
Caliţa, Mihaela
Burtea, Elena Daniela
Cârţu, Dan
Leru, Polliana Mihaela
author_facet Cazacu, Sergiu Marian
Săftoiu, Adrian
Iordache, Sevastiţa
Ghiluşi, Mirela-Corina
Georgescu, Claudia Valentina
Iovănescu, Vlad Florin
Neagoe, Carmen Daniela
Streba, Liliana
Caliţa, Mihaela
Burtea, Elena Daniela
Cârţu, Dan
Leru, Polliana Mihaela
author_sort Cazacu, Sergiu Marian
collection PubMed
description Colorectal carcinoma represents a major cause of mortality and 0.2–12% of resected colonic polyps have malignant cells inside. We performed a retrospective study of patients with resected polyps during a period of 13 years. A total of 905 patients had 2033 polyps removed; 122 polyps (109 patients) had malignant cells. Prevalence of malignant polyps with submucosal invasion was 1.23% and for all polyps with malignant cells was 6%; malignant polyps had a larger size (23.44 mm mean diameter) vs benign polyps (9.63 mm); the risk of malignancy was increased in polyps larger than 10 mm, in lateral spreading lesions and in Paris types 0-Ip, 0-Isp, in sigmoid, descending colon and rectum, in sessile serrated adenoma and traditional serrate adenoma subtypes of serrated lesions and in tubulovillous and villous adenoma. In 18 cases surgery was performed, in 62 patients only colonoscopic follow-up was made and in 35 patients no colonoscopic follow-up was recorded. From initially endoscopic resected polyps, recurrence was noted in seven (11.3%) cases; there was a trend toward association with depth of invasion, piecemeal resection, right and rectum location, sessile and lateral spreading type and pathological subtype. In surgical group, post-therapeutic staging was available in 11 cases; nodal involvement was noted in three (27.27%) cases; none had lymphatic or vascular invasion in endoscopically resected polyps. Four patients with no macroscopic local recurrence underwent surgery with no residual tumor. The rate of metastasis was 16.67% in surgical group and 1.61% in endoscopic group. Evaluation of lymph node (LN) invasion was available for 11 operated patients, with LN invasion (N1) in three patients, local residual tumoral tissue in one patient with incomplete resection and no residual tumor (R0 resection) in four patients with endoscopic resection before surgery.
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spelling pubmed-92896942022-07-21 Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy Cazacu, Sergiu Marian Săftoiu, Adrian Iordache, Sevastiţa Ghiluşi, Mirela-Corina Georgescu, Claudia Valentina Iovănescu, Vlad Florin Neagoe, Carmen Daniela Streba, Liliana Caliţa, Mihaela Burtea, Elena Daniela Cârţu, Dan Leru, Polliana Mihaela Rom J Morphol Embryol Original Paper Colorectal carcinoma represents a major cause of mortality and 0.2–12% of resected colonic polyps have malignant cells inside. We performed a retrospective study of patients with resected polyps during a period of 13 years. A total of 905 patients had 2033 polyps removed; 122 polyps (109 patients) had malignant cells. Prevalence of malignant polyps with submucosal invasion was 1.23% and for all polyps with malignant cells was 6%; malignant polyps had a larger size (23.44 mm mean diameter) vs benign polyps (9.63 mm); the risk of malignancy was increased in polyps larger than 10 mm, in lateral spreading lesions and in Paris types 0-Ip, 0-Isp, in sigmoid, descending colon and rectum, in sessile serrated adenoma and traditional serrate adenoma subtypes of serrated lesions and in tubulovillous and villous adenoma. In 18 cases surgery was performed, in 62 patients only colonoscopic follow-up was made and in 35 patients no colonoscopic follow-up was recorded. From initially endoscopic resected polyps, recurrence was noted in seven (11.3%) cases; there was a trend toward association with depth of invasion, piecemeal resection, right and rectum location, sessile and lateral spreading type and pathological subtype. In surgical group, post-therapeutic staging was available in 11 cases; nodal involvement was noted in three (27.27%) cases; none had lymphatic or vascular invasion in endoscopically resected polyps. Four patients with no macroscopic local recurrence underwent surgery with no residual tumor. The rate of metastasis was 16.67% in surgical group and 1.61% in endoscopic group. Evaluation of lymph node (LN) invasion was available for 11 operated patients, with LN invasion (N1) in three patients, local residual tumoral tissue in one patient with incomplete resection and no residual tumor (R0 resection) in four patients with endoscopic resection before surgery. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2021 2022-05-20 /pmc/articles/PMC9289694/ /pubmed/35673811 http://dx.doi.org/10.47162/RJME.62.4.04 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Cazacu, Sergiu Marian
Săftoiu, Adrian
Iordache, Sevastiţa
Ghiluşi, Mirela-Corina
Georgescu, Claudia Valentina
Iovănescu, Vlad Florin
Neagoe, Carmen Daniela
Streba, Liliana
Caliţa, Mihaela
Burtea, Elena Daniela
Cârţu, Dan
Leru, Polliana Mihaela
Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title_full Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title_fullStr Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title_full_unstemmed Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title_short Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
title_sort factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289694/
https://www.ncbi.nlm.nih.gov/pubmed/35673811
http://dx.doi.org/10.47162/RJME.62.4.04
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