Explaining unexplained hypoglycemia: How LC-MS/MS can help

Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin ana...

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Detalles Bibliográficos
Autores principales: Ackermans, M.T., Hopman, J., Heijboer, A.C., Siegelaar, S.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289730/
https://www.ncbi.nlm.nih.gov/pubmed/35860389
http://dx.doi.org/10.1016/j.plabm.2022.e00291
Descripción
Sumario:Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened.

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