Explaining unexplained hypoglycemia: How LC-MS/MS can help

Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin ana...

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Detalles Bibliográficos
Autores principales: Ackermans, M.T., Hopman, J., Heijboer, A.C., Siegelaar, S.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289730/
https://www.ncbi.nlm.nih.gov/pubmed/35860389
http://dx.doi.org/10.1016/j.plabm.2022.e00291
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author Ackermans, M.T.
Hopman, J.
Heijboer, A.C.
Siegelaar, S.E.
author_facet Ackermans, M.T.
Hopman, J.
Heijboer, A.C.
Siegelaar, S.E.
author_sort Ackermans, M.T.
collection PubMed
description Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened.
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spelling pubmed-92897302022-07-19 Explaining unexplained hypoglycemia: How LC-MS/MS can help Ackermans, M.T. Hopman, J. Heijboer, A.C. Siegelaar, S.E. Pract Lab Med Case Report Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened. Elsevier 2022-07-12 /pmc/articles/PMC9289730/ /pubmed/35860389 http://dx.doi.org/10.1016/j.plabm.2022.e00291 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ackermans, M.T.
Hopman, J.
Heijboer, A.C.
Siegelaar, S.E.
Explaining unexplained hypoglycemia: How LC-MS/MS can help
title Explaining unexplained hypoglycemia: How LC-MS/MS can help
title_full Explaining unexplained hypoglycemia: How LC-MS/MS can help
title_fullStr Explaining unexplained hypoglycemia: How LC-MS/MS can help
title_full_unstemmed Explaining unexplained hypoglycemia: How LC-MS/MS can help
title_short Explaining unexplained hypoglycemia: How LC-MS/MS can help
title_sort explaining unexplained hypoglycemia: how lc-ms/ms can help
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289730/
https://www.ncbi.nlm.nih.gov/pubmed/35860389
http://dx.doi.org/10.1016/j.plabm.2022.e00291
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