Cargando…

CLK2 Expression Is Associated with the Progression of Colorectal Cancer and Is a Prognostic Biomarker

BACKGROUND: CLK2 is a splicing regulator and expressed ubiquitously in various malignancies. The study is aimed at exploring the potential roles of CLK2 in the development of colorectal cancer (CRC). METHODS: Real-time PCR and analyses of The Cancer Genome Atlas (TCGA) and Human Protein Atlas (HPA)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Jiarui, Lin, Guixing, Chen, Binbin, Yuan, Jinpeng, Zhuang, Yezhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289758/ https://www.ncbi.nlm.nih.gov/pubmed/35860803 http://dx.doi.org/10.1155/2022/7250127

Ejemplares similares

SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4
por: Tiek, Deanna, et al.
Publicado: (2023)

Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism
por: Zhou, Qingxin, et al.
Publicado: (2020)

Controlling clots with Clk1
por: Williams, Ruth
Publicado: (2006)

CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics
por: Geoghegan, Vincent, et al.
Publicado: (2022)

INHBB Is a Novel Prognostic Biomarker Associated with Cancer-Promoting Pathways in Colorectal Cancer
por: Yuan, Jinpeng, et al.
Publicado: (2020)

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment
por: Zu, Mian, et al.
Publicado: (2015)

MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
por: Xue, Meng, et al.
Publicado: (2022)

RNA-Binding Proteins CLK1 and POP7 as Biomarkers for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma
por: Yang, Xiuping, et al.
Publicado: (2021)

CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma
por: Li, Hua, et al.
Publicado: (2019)

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
por: Saldivia, Manuel, et al.
Publicado: (2020)

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
por: Dahal, Subha, et al.
Publicado: (2022)

The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression
por: Hong, Hanqing, et al.
Publicado: (2019)

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
por: Murai, Aiko, et al.
Publicado: (2020)

Integrative Gene Expression Profiling Analysis to Investigate Potential Prognostic Biomarkers for Colorectal Cancer
por: Liu, Xinkui, et al.
Publicado: (2020)

Identification of Tumorigenic and Prognostic Biomarkers in Colorectal Cancer Based on microRNA Expression Profiles
por: Shi, Yuntao, et al.
Publicado: (2020)

Expression of MYSM1 is associated with tumor progression in colorectal cancer
por: Li, Yongmin, et al.
Publicado: (2017)

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
por: Wong, Raymond, et al.
Publicado: (2011)

Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
por: Wang, Zhenguo, et al.
Publicado: (2021)

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing
por: Fedorov, Oleg, et al.
Publicado: (2011)

Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members
por: Prak, Krisna, et al.
Publicado: (2015)

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis
por: Yuan, Jinpeng, et al.
Publicado: (2020)

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2
por: Bulos, Maya L., et al.
Publicado: (2023)

Correction: Expression of MYSM1 is associated with tumor progression in colorectal cancer
por: Li, Yongmin, et al.
Publicado: (2017)

Dual TTK/CLK2 inhibitor, CC‐671, selectively antagonizes ABCG2‐mediated multidrug resistance in lung cancer cells
por: Wu, Zhuo‐Xun, et al.
Publicado: (2020)

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
por: Bullock, Alex N., et al.
Publicado: (2009)

Circadian Rhythms in Visual Responsiveness in the Behaviorally Arrhythmic Drosophila Clock Mutant Clk(Jrk)
por: Nippe, Olivia M., et al.
Publicado: (2017)

CLK2 blockade modulates alternative splicing compromising MYC‐driven breast tumors
por: Salvador, Fernando, et al.
Publicado: (2018)

A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
por: Liu, Ju-Ling, et al.
Publicado: (2017)

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
por: Dao, Viet Hung, et al.
Publicado: (2021)

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency
por: ElHady, Ahmed K., et al.
Publicado: (2021)

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
por: Bowler, Elizabeth, et al.
Publicado: (2018)

Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis
por: Lin, Hong, et al.
Publicado: (2020)

A Novel Immune-Related Prognostic Biomarker and Target Associated With Malignant Progression of Glioma
por: Zhang, Yu, et al.
Publicado: (2021)

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
por: Uzor, Simon, et al.
Publicado: (2021)

Expression analysis of microRNA as prognostic biomarkers in colorectal cancer
por: Yang, Jie, et al.
Publicado: (2016)

A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei
por: Saldivia, Manuel, et al.
Publicado: (2021)

Octopamine Rescues Endurance and Climbing Speed in Drosophila Clk(out) Mutants with Circadian Rhythm Disruption
por: Safdar, Maryam, et al.
Publicado: (2023)

Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression
por: Jang, Bo Gun, et al.
Publicado: (2018)

Downregulation of CLCA4 expression is associated with the development and progression of colorectal cancer
por: Wei, Lihui, et al.
Publicado: (2020)

Prognostic Value of Colorectal Cancer Biomarkers
por: Bianchi, Paolo, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_aq0m355me4ekacm5lo5k54cha7