Cargando…

MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery smooth muscle cells (PASMCs) and lungs of pulmonary hypertension (PH) patients and rodents with experimental PH. We found tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Tianji, Sun, Miranda R., Zhou, Qiyuan, Guzman, Alyssa M., Ramchandran, Ramaswamy, Chen, Jiwang, Fraidenburg, Dustin R., Ganesh, Balaji, Maienschein-Cline, Mark, Obrietan, Karl, Raj, J. Usha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289783/ https://www.ncbi.nlm.nih.gov/pubmed/35892089 http://dx.doi.org/10.1016/j.omtn.2022.06.008

Ejemplares similares

Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice
por: Chen, Tianji, et al.
Publicado: (2022)

Sugen, hypoxia and the lung circulation
por: Voelkel, Norbert F., et al.
Publicado: (2021)

Transpulmonary amino acid metabolism in the sugen hypoxia model of pulmonary hypertension
por: Philip, Nicolas, et al.
Publicado: (2023)

Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat
por: Docherty, Craig K., et al.
Publicado: (2020)

Increased Eicosanoid Levels in the Sugen/Chronic Hypoxia Model of Severe Pulmonary Hypertension
por: Al-Husseini, Aysar, et al.
Publicado: (2015)

Spatial and temporal resolution of metabolic dysregulation in the Sugen hypoxia model of pulmonary hypertension
por: Simpson, Catherine E., et al.
Publicado: (2023)

Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension
por: Bogaard, Harm J., et al.
Publicado: (2019)

IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice
por: Indralingam, Cynthia S., et al.
Publicado: (2022)

Using extracellular matrix derived from sugen-chronic hypoxia lung tissue to study pulmonary arterial hypertension
por: Link, Patrick A., et al.
Publicado: (2023)

Sugen–morphine model of pulmonary arterial hypertension
por: Agarwal, Stuti, et al.
Publicado: (2020)

Intratracheal Administration of Prostacyclin Analogue–incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension
por: Akagi, Satoshi, et al.
Publicado: (2016)

The selective PGI(2) receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats
por: Honda, Yohei, et al.
Publicado: (2020)

Response to: Are endothelial cell proliferation and mesenchymal transition as distinguishing characteristics of 3-week Sugen5416/hypoxia mice model?
por: Rodor, Julie, et al.
Publicado: (2023)

Effects of the Oral Angiotensin II Type 2 Receptor Agonist C21 in Sugen-Hypoxia Induced Pulmonary Hypertension in Rats
por: Tornling, Göran, et al.
Publicado: (2023)

Upregulated Copper Transporters in Hypoxia-Induced Pulmonary Hypertension
por: Zimnicka, Adriana M., et al.
Publicado: (2014)

Isolated heart model demonstrates evidence of contractile and diastolic dysfunction in right ventricles from rats with sugen/hypoxia‐induced pulmonary hypertension
por: Neto‐Neves, Evandro M., et al.
Publicado: (2017)

Reply to Bogaard et al.: Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension
por: Kojonazarov, Baktybek, et al.
Publicado: (2019)

Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging
por: Jayasekera, Geeshath, et al.
Publicado: (2020)

The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still “the One:” A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman
por: Bogaard, Harm J., et al.
Publicado: (2020)

Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model
por: Morales-Cano, Daniel, et al.
Publicado: (2023)

Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT
por: van der Have, Oscar, et al.
Publicado: (2022)

Corrigendum: Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model
por: Morales-Cano, Daniel, et al.
Publicado: (2023)

MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells
por: Zeng, Yan, et al.
Publicado: (2016)

miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation
por: Chen, Tianji, et al.
Publicado: (2016)

The Role of Intermittent Hypoxia on the Proliferative Inhibition of Rat Cerebellar Astrocytes
por: Chiu, Sheng-Chun, et al.
Publicado: (2015)

Commentary: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock
por: Mendoza-Viveros, Lucia, et al.
Publicado: (2017)

Commentary: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock
por: Mendoza-Viveros, Lucia, et al.
Publicado: (2018)

mRNA-to-protein translation in hypoxia
por: Chee, Nancy T., et al.
Publicado: (2019)

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells
por: Zeng, Yan, et al.
Publicado: (2015)

The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition
por: Aten, Sydney, et al.
Publicado: (2016)

miR-212 promotes renal interstitial fibrosis by inhibiting hypoxia-inducible factor 1-α inhibitor
por: Zhang, Yun, et al.
Publicado: (2021)

Proliferative Pathways of Vascular Smooth Muscle Cells in Response to Intermittent Hypoxia
por: Kyotani, Yoji, et al.
Publicado: (2019)

Regulation of angiogenesis by hypoxia: the role of microRNA
por: Madanecki, Piotr, et al.
Publicado: (2012)

Hypoxia regulates RNA splicing of HIF targets
por: Hu, Cheng-Jun
Publicado: (2014)

Selection of RNA aptamers targeting hypoxia in cancer
por: Nuzzo, Silvia, et al.
Publicado: (2022)

Functional Balancing of the Hypoxia Regulators RAP2.12 and HRA1 Takes Place in vivo in Arabidopsis thaliana Plants
por: Giuntoli, Beatrice, et al.
Publicado: (2017)

Proliferative diabetic retinopathy: predictive and preventive measures at hypoxia induced retinal changes
por: Josifova, Tatjana, et al.
Publicado: (2010)

Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells
por: Burek, Malgorzata, et al.
Publicado: (2019)

Surviving hypoxia by modulation of mRNA translation rate
por: Fähling, Michael
Publicado: (2009)

Hypoxia and Hypoglycemia synergistically regulate mRNA stability
por: Carraway, Kristen R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_86sk09ua2kshabq68tn2ijqg5h