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Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease
BACKGROUND/AIMS: Metabolic dysfunction (MD)-associated fatty liver disease is a new positive diagnostic criterion based on hepatic steatosis and MD. However, a comprehensive evaluation on the association of MD and hepatic steatosis with incident cardiovascular disease (CVD) has yet to be performed....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Office of Gut and Liver
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289825/ https://www.ncbi.nlm.nih.gov/pubmed/34730107 http://dx.doi.org/10.5009/gnl210256 |
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author | Jeong, Seogsong Oh, Yun Hwan Choi, Seulggie Chang, Jooyoung Kim, Sung Min Son, Joung Sik Lee, Gyeongsil Kim, Won Park, Sang Min |
author_facet | Jeong, Seogsong Oh, Yun Hwan Choi, Seulggie Chang, Jooyoung Kim, Sung Min Son, Joung Sik Lee, Gyeongsil Kim, Won Park, Sang Min |
author_sort | Jeong, Seogsong |
collection | PubMed |
description | BACKGROUND/AIMS: Metabolic dysfunction (MD)-associated fatty liver disease is a new positive diagnostic criterion based on hepatic steatosis and MD. However, a comprehensive evaluation on the association of MD and hepatic steatosis with incident cardiovascular disease (CVD) has yet to be performed. METHODS: This retrospective cohort study included 333,389 participants from the Korean National Health Insurance Service database who received a health examination between 2009 and 2010. Hepatic steatosis was defined using the Korean National Health and Nutrition Examination Survey-derived nonalcoholic fatty liver disease scoring system. Cox proportional hazards regression was adopted to determine the adjusted hazard ratio (aHR) with 95% confidence interval (CI) for CVD according to the presence of hepatic steatosis and MD, as well as the composite term. RESULTS: This study included 179,437 men and 153,952 women with a median age of 57 years. Hepatic steatosis with MD (aHR, 2.00; 95% CI, 1.89 to 2.13) and without MD (aHR, 1.30; 95% CI, 1.10 to 1.54) significantly increased the risk of CVD compared to no steatosis without MD (reference). However, steatosis revealed no significant difference in the risk of CVD compared to no steatosis among participants with one MD (aHR, 1.09; 95% CI, 0.91 to 1.30). In participants with steatosis, the presence of one and ≥2 MDs had aHR values of 1.25 (95% CI, 0.87 to 1.79) and 1.71 (95% CI, 1.22 to 2.41), respectively, compared to no MD. CONCLUSIONS: Combined consideration of hepatic steatosis and MD was significantly associated with increased CVD risk and showed better predictive performance for CVD than hepatic steatosis or MD alone. |
format | Online Article Text |
id | pubmed-9289825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-92898252022-07-18 Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease Jeong, Seogsong Oh, Yun Hwan Choi, Seulggie Chang, Jooyoung Kim, Sung Min Son, Joung Sik Lee, Gyeongsil Kim, Won Park, Sang Min Gut Liver Original Article BACKGROUND/AIMS: Metabolic dysfunction (MD)-associated fatty liver disease is a new positive diagnostic criterion based on hepatic steatosis and MD. However, a comprehensive evaluation on the association of MD and hepatic steatosis with incident cardiovascular disease (CVD) has yet to be performed. METHODS: This retrospective cohort study included 333,389 participants from the Korean National Health Insurance Service database who received a health examination between 2009 and 2010. Hepatic steatosis was defined using the Korean National Health and Nutrition Examination Survey-derived nonalcoholic fatty liver disease scoring system. Cox proportional hazards regression was adopted to determine the adjusted hazard ratio (aHR) with 95% confidence interval (CI) for CVD according to the presence of hepatic steatosis and MD, as well as the composite term. RESULTS: This study included 179,437 men and 153,952 women with a median age of 57 years. Hepatic steatosis with MD (aHR, 2.00; 95% CI, 1.89 to 2.13) and without MD (aHR, 1.30; 95% CI, 1.10 to 1.54) significantly increased the risk of CVD compared to no steatosis without MD (reference). However, steatosis revealed no significant difference in the risk of CVD compared to no steatosis among participants with one MD (aHR, 1.09; 95% CI, 0.91 to 1.30). In participants with steatosis, the presence of one and ≥2 MDs had aHR values of 1.25 (95% CI, 0.87 to 1.79) and 1.71 (95% CI, 1.22 to 2.41), respectively, compared to no MD. CONCLUSIONS: Combined consideration of hepatic steatosis and MD was significantly associated with increased CVD risk and showed better predictive performance for CVD than hepatic steatosis or MD alone. Editorial Office of Gut and Liver 2022-07-15 2021-11-03 /pmc/articles/PMC9289825/ /pubmed/34730107 http://dx.doi.org/10.5009/gnl210256 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jeong, Seogsong Oh, Yun Hwan Choi, Seulggie Chang, Jooyoung Kim, Sung Min Son, Joung Sik Lee, Gyeongsil Kim, Won Park, Sang Min Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title | Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title_full | Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title_fullStr | Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title_full_unstemmed | Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title_short | Metabolic Dysfunction-Associated Fatty Liver Disease Better Predicts Incident Cardiovascular Disease |
title_sort | metabolic dysfunction-associated fatty liver disease better predicts incident cardiovascular disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289825/ https://www.ncbi.nlm.nih.gov/pubmed/34730107 http://dx.doi.org/10.5009/gnl210256 |
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