CD40 Agonists Alter the Pancreatic Cancer Microenvironment by Shifting the Macrophage Phenotype toward M1 and Suppress Human Pancreatic Cancer in Organotypic Slice Cultures

BACKGROUND/AIMS: CD40 agonists are thought to generate antitumor effects on pancreatic cancer via macrophages and T cells. We aimed to investigate the role of CD40 agonists in the differentiation of macrophages and treatment of human pancreatic adenocarcinoma. METHODS: Immunohistochemistry was perfo...

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Detalles Bibliográficos
Autores principales: Lim, Chae Yoon, Chang, Jae Hyuck, Lee, Won Sun, Kim, Jeana, Park, Il Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289829/
https://www.ncbi.nlm.nih.gov/pubmed/34933280
http://dx.doi.org/10.5009/gnl210311

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