Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology

[Image: see text] Macrocyclic peptides can disrupt previously intractable protein–protein interactions (PPIs) relevant to oncology targets such as KRAS. Early hits often lack cellular activity and require meticulous improvement of affinity, permeability, and metabolic stability to become viable lead...

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Detalles Bibliográficos
Autores principales: Garrigou, Michael, Sauvagnat, Bérengère, Duggal, Ruchia, Boo, Nicole, Gopal, Pooja, Johnston, Jennifer M., Partridge, Anthony, Sawyer, Tomi, Biswas, Kaustav, Boyer, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289880/
https://www.ncbi.nlm.nih.gov/pubmed/35707970
http://dx.doi.org/10.1021/acs.jmedchem.2c00154

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