Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies

[Image: see text] SETD2, a lysine N-methyltransferase, is a histone methyltransferase that plays an important role in various cellular processes and was identified as a target of interest in multiple myeloma that features a t(4,14) translocation. We recently reported the discovery of a novel small-m...

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Detalles Bibliográficos
Autores principales: Alford, Joshua S., Lampe, John W., Brach, Dorothy, Chesworth, Richard, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Kutok, Jeffrey L., Raimondi, Alejandra, Riera, Thomas V., Shook, Brian, Tang, Cuyue, Totman, Jennifer, Farrow, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290024/
https://www.ncbi.nlm.nih.gov/pubmed/35859865
http://dx.doi.org/10.1021/acsmedchemlett.2c00167

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