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Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study
BACKGROUND: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. METHODS: A retrospective analysis was conducted in NPC patients with liver,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290165/ https://www.ncbi.nlm.nih.gov/pubmed/35860835 http://dx.doi.org/10.1177/17588359221112486 |
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author | Zhang, Meng-Xia Liu, Ting You, Rui Zou, Xiong Liu, Yong-Long Ding, Xi Duan, Chong-Yang Xu, Han-Shi Liu, You-Ping Jiang, Rou Wang, Zhi-Qiang Lin, Chao Xie, Yu-Long Chen, Si-Yuan Ouyang, Yan-Feng Xie, Ruo-Qi Hua, Yi-Jun Sun, Rui Huang, Pei-Yu Wang, Shun-Lan Chen, Ming-Yuan |
author_facet | Zhang, Meng-Xia Liu, Ting You, Rui Zou, Xiong Liu, Yong-Long Ding, Xi Duan, Chong-Yang Xu, Han-Shi Liu, You-Ping Jiang, Rou Wang, Zhi-Qiang Lin, Chao Xie, Yu-Long Chen, Si-Yuan Ouyang, Yan-Feng Xie, Ruo-Qi Hua, Yi-Jun Sun, Rui Huang, Pei-Yu Wang, Shun-Lan Chen, Ming-Yuan |
author_sort | Zhang, Meng-Xia |
collection | PubMed |
description | BACKGROUND: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. METHODS: A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall survival (OS) rate was analyzed using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using the Cox hazard model. Subgroup analyses evaluating the effect of LT were performed for prespecified covariates. Propensity score matching was applied to homogenize the compared arms. RESULTS: Overall, 2041 of 2962 patients were eligible for analysis. At a median follow-up of 43.4 months, the 5-year OS improved by an absolute difference of 14.6%, from 46.2% in the LT group versus 31.6% in the non-LT group, which led to a hazard ratio of 0.634 for death (p < 0.001). Matched-pair analyses confirmed that LT was associated with improved OS (p = 0.003), and the survival benefits of LT remained consistent in the subcohorts of liver and lung metastasis (p = 0.009 and p = 0.007, respectively) but not of bone metastasis (BoM; p = 0.614). Radiotherapy was predominantly used for BoM and biological effective dose (BED) >60 Gy was found to yield more survival benefit than that of BED ⩽ 60 Gy. CONCLUSIONS: The addition of LT directed at metastasis has demonstrated an improvement to OS compared with non-LT group in the present matched-pair study, especially for patients with liver and/or lung metastases. |
format | Online Article Text |
id | pubmed-9290165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-92901652022-07-19 Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study Zhang, Meng-Xia Liu, Ting You, Rui Zou, Xiong Liu, Yong-Long Ding, Xi Duan, Chong-Yang Xu, Han-Shi Liu, You-Ping Jiang, Rou Wang, Zhi-Qiang Lin, Chao Xie, Yu-Long Chen, Si-Yuan Ouyang, Yan-Feng Xie, Ruo-Qi Hua, Yi-Jun Sun, Rui Huang, Pei-Yu Wang, Shun-Lan Chen, Ming-Yuan Ther Adv Med Oncol Original Research BACKGROUND: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. METHODS: A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall survival (OS) rate was analyzed using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using the Cox hazard model. Subgroup analyses evaluating the effect of LT were performed for prespecified covariates. Propensity score matching was applied to homogenize the compared arms. RESULTS: Overall, 2041 of 2962 patients were eligible for analysis. At a median follow-up of 43.4 months, the 5-year OS improved by an absolute difference of 14.6%, from 46.2% in the LT group versus 31.6% in the non-LT group, which led to a hazard ratio of 0.634 for death (p < 0.001). Matched-pair analyses confirmed that LT was associated with improved OS (p = 0.003), and the survival benefits of LT remained consistent in the subcohorts of liver and lung metastasis (p = 0.009 and p = 0.007, respectively) but not of bone metastasis (BoM; p = 0.614). Radiotherapy was predominantly used for BoM and biological effective dose (BED) >60 Gy was found to yield more survival benefit than that of BED ⩽ 60 Gy. CONCLUSIONS: The addition of LT directed at metastasis has demonstrated an improvement to OS compared with non-LT group in the present matched-pair study, especially for patients with liver and/or lung metastases. SAGE Publications 2022-07-15 /pmc/articles/PMC9290165/ /pubmed/35860835 http://dx.doi.org/10.1177/17588359221112486 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Zhang, Meng-Xia Liu, Ting You, Rui Zou, Xiong Liu, Yong-Long Ding, Xi Duan, Chong-Yang Xu, Han-Shi Liu, You-Ping Jiang, Rou Wang, Zhi-Qiang Lin, Chao Xie, Yu-Long Chen, Si-Yuan Ouyang, Yan-Feng Xie, Ruo-Qi Hua, Yi-Jun Sun, Rui Huang, Pei-Yu Wang, Shun-Lan Chen, Ming-Yuan Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title | Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title_full | Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title_fullStr | Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title_full_unstemmed | Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title_short | Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
title_sort | efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290165/ https://www.ncbi.nlm.nih.gov/pubmed/35860835 http://dx.doi.org/10.1177/17588359221112486 |
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