Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography

BACKGROUND: To investigate the effects of vitamin C on central retinal thickness and choroidal thickness. METHODS: A total of 69 patients diagnosed with vitamin C deficiency and 1:1 age- and gender-matched 69 healthy individuals with normal serum vitamin C were included in this study. Demographic ch...

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Autores principales: Qian, Yiwen, Wang, Luoziyi, Qiang, Xinfang, Weng, Huan, Jiang, Jing, Che, Xin, Li, Qingjian, Wang, Zhiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290199/
https://www.ncbi.nlm.nih.gov/pubmed/35850684
http://dx.doi.org/10.1186/s12886-022-02530-8
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author Qian, Yiwen
Wang, Luoziyi
Qiang, Xinfang
Weng, Huan
Jiang, Jing
Che, Xin
Li, Qingjian
Wang, Zhiliang
author_facet Qian, Yiwen
Wang, Luoziyi
Qiang, Xinfang
Weng, Huan
Jiang, Jing
Che, Xin
Li, Qingjian
Wang, Zhiliang
author_sort Qian, Yiwen
collection PubMed
description BACKGROUND: To investigate the effects of vitamin C on central retinal thickness and choroidal thickness. METHODS: A total of 69 patients diagnosed with vitamin C deficiency and 1:1 age- and gender-matched 69 healthy individuals with normal serum vitamin C were included in this study. Demographic characteristics of the individuals were collected. All patients underwent a comprehensive ophthalmic examination. Subfoveal choroidal thickness and retinal thickness were measured using a swept-source optical coherence tomography (SS-OCT). RESULTS: The average retinal thickness was 269.07 ± 13.51 μm in the vitamin C deficiency group and 276.92 ± 13.51 μm in the control group. The average choroidal thickness was 195.62 ± 66.40 μm in the in the vitamin C deficiency group and 238.86 ± 55.08 μm in the control group. There was a significant decrease in both average choroidal thickness and retinal thickness in vitamin C deficiency group compared with normal individuals (p < 0.001, and = 0.001 respectively). CONCLUSION: The central retinal and choroidal thickness were thinner in vitamin C deficiency group compared with normal individuals. These findings suggested that vitamin C deficiency might play an important role in retinal and choroidal diseases.
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spelling pubmed-92901992022-07-19 Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography Qian, Yiwen Wang, Luoziyi Qiang, Xinfang Weng, Huan Jiang, Jing Che, Xin Li, Qingjian Wang, Zhiliang BMC Ophthalmol Research BACKGROUND: To investigate the effects of vitamin C on central retinal thickness and choroidal thickness. METHODS: A total of 69 patients diagnosed with vitamin C deficiency and 1:1 age- and gender-matched 69 healthy individuals with normal serum vitamin C were included in this study. Demographic characteristics of the individuals were collected. All patients underwent a comprehensive ophthalmic examination. Subfoveal choroidal thickness and retinal thickness were measured using a swept-source optical coherence tomography (SS-OCT). RESULTS: The average retinal thickness was 269.07 ± 13.51 μm in the vitamin C deficiency group and 276.92 ± 13.51 μm in the control group. The average choroidal thickness was 195.62 ± 66.40 μm in the in the vitamin C deficiency group and 238.86 ± 55.08 μm in the control group. There was a significant decrease in both average choroidal thickness and retinal thickness in vitamin C deficiency group compared with normal individuals (p < 0.001, and = 0.001 respectively). CONCLUSION: The central retinal and choroidal thickness were thinner in vitamin C deficiency group compared with normal individuals. These findings suggested that vitamin C deficiency might play an important role in retinal and choroidal diseases. BioMed Central 2022-07-18 /pmc/articles/PMC9290199/ /pubmed/35850684 http://dx.doi.org/10.1186/s12886-022-02530-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Qian, Yiwen
Wang, Luoziyi
Qiang, Xinfang
Weng, Huan
Jiang, Jing
Che, Xin
Li, Qingjian
Wang, Zhiliang
Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title_full Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title_fullStr Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title_full_unstemmed Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title_short Choroidal and retinal thickness in patients with vitamin C deficiency using swept-source optical coherence tomography
title_sort choroidal and retinal thickness in patients with vitamin c deficiency using swept-source optical coherence tomography
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290199/
https://www.ncbi.nlm.nih.gov/pubmed/35850684
http://dx.doi.org/10.1186/s12886-022-02530-8
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