Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

AIM: Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is often deleted or epigenetically silenced in tumors....

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Detalles Bibliográficos
Autores principales: Hanna, Ann, Nixon, Mellissa J., Estrada, M. Valeria, Sanchez, Violeta, Sheng, Quanhu, Opalenik, Susan R., Toren, Abigail L., Bauer, Joshua, Owens, Phillip, Mason, Frank M., Cook, Rebecca S., Sanders, Melinda E., Arteaga, Carlos L., Balko, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290202/
https://www.ncbi.nlm.nih.gov/pubmed/35850776
http://dx.doi.org/10.1186/s13058-022-01542-y

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