Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells

BACKGROUND: The requirement of the Mek1 inhibitor (iMek1) during naïve pluripotency maintenance results from the activation of the Mek1-Erk1/2 (Mek/Erk) signaling pathway upon leukemia inhibitory factor (LIF) stimulation. METHODS: Through a meta-analysis of previous genome-wide screening for negativ...

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Detalles Bibliográficos
Autores principales: Kim, Seong-Min, Kwon, Eun-Ji, Kim, Yun-Jeong, Go, Young-Hyun, Oh, Ji-Young, Park, Seokwoo, Do, Jeong Tae, Kim, Keun-Tae, Cha, Hyuk-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290224/
https://www.ncbi.nlm.nih.gov/pubmed/35850773
http://dx.doi.org/10.1186/s13287-022-02976-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290224/
https://www.ncbi.nlm.nih.gov/pubmed/35850773
http://dx.doi.org/10.1186/s13287-022-02976-z

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