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Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells

BACKGROUND: The requirement of the Mek1 inhibitor (iMek1) during naïve pluripotency maintenance results from the activation of the Mek1-Erk1/2 (Mek/Erk) signaling pathway upon leukemia inhibitory factor (LIF) stimulation. METHODS: Through a meta-analysis of previous genome-wide screening for negativ...

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Detalles Bibliográficos
Autores principales:	Kim, Seong-Min, Kwon, Eun-Ji, Kim, Yun-Jeong, Go, Young-Hyun, Oh, Ji-Young, Park, Seokwoo, Do, Jeong Tae, Kim, Keun-Tae, Cha, Hyuk-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290224/ https://www.ncbi.nlm.nih.gov/pubmed/35850773 http://dx.doi.org/10.1186/s13287-022-02976-z

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