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Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi
Human infectious diseases caused by various microbial pathogens, in general, impact a large population of individuals every year. These microbial diseases that spread quickly remain to be a big issue in various health-related domains and to withstand the negative drug impacts, the antimicrobial-resi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290337/ https://www.ncbi.nlm.nih.gov/pubmed/35874656 http://dx.doi.org/10.1016/j.sjbs.2022.103376 |
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author | Qadri, Hafsa Haseeb Shah, Abdul Mudasir Ahmad, Syed Alshehri, Bader Almilaibary, Abdullah Ahmad Mir, Manzoor |
author_facet | Qadri, Hafsa Haseeb Shah, Abdul Mudasir Ahmad, Syed Alshehri, Bader Almilaibary, Abdullah Ahmad Mir, Manzoor |
author_sort | Qadri, Hafsa |
collection | PubMed |
description | Human infectious diseases caused by various microbial pathogens, in general, impact a large population of individuals every year. These microbial diseases that spread quickly remain to be a big issue in various health-related domains and to withstand the negative drug impacts, the antimicrobial-resistant pathogenic microbial organisms (pathogenic bacteria and pathogenic fungi) have developed a variety of resistance processes against many antimicrobial drug classes. During the COVID-19 outbreak, there seems to be an upsurge in drug and multidrug resistant-associated pathogenic microbial species. The preponderance of existing antimicrobials isn’t completely effective, which limits their application in clinical settings. Several naturally occurring chemicals produced from bacteria, plants, animals, marine species, and other sources are now being studied for antimicrobial characteristics. These natural antimicrobial compounds extracted from different sources have been demonstrated to be effective against a variety of diseases, although plants remain the most abundant source. These compounds have shown promise in reducing the microbial diseases linked to the development of drug tolerance and resistance. This paper offers a detailed review of some of the most vital and promising natural compounds and their derivatives against various human infectious microbial organisms. The inhibitory action of different natural antimicrobial compounds, and their possible mechanism of antimicrobial action against a range of pathogenic fungal and bacterial organisms, is provided. The review will be useful in refining current antimicrobial (antifungal and antibacterial) medicines as well as establishing new treatment strategies to tackle the rising number of human bacterial and fungal-associated infections. |
format | Online Article Text |
id | pubmed-9290337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92903372022-07-18 Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi Qadri, Hafsa Haseeb Shah, Abdul Mudasir Ahmad, Syed Alshehri, Bader Almilaibary, Abdullah Ahmad Mir, Manzoor Saudi J Biol Sci Review Human infectious diseases caused by various microbial pathogens, in general, impact a large population of individuals every year. These microbial diseases that spread quickly remain to be a big issue in various health-related domains and to withstand the negative drug impacts, the antimicrobial-resistant pathogenic microbial organisms (pathogenic bacteria and pathogenic fungi) have developed a variety of resistance processes against many antimicrobial drug classes. During the COVID-19 outbreak, there seems to be an upsurge in drug and multidrug resistant-associated pathogenic microbial species. The preponderance of existing antimicrobials isn’t completely effective, which limits their application in clinical settings. Several naturally occurring chemicals produced from bacteria, plants, animals, marine species, and other sources are now being studied for antimicrobial characteristics. These natural antimicrobial compounds extracted from different sources have been demonstrated to be effective against a variety of diseases, although plants remain the most abundant source. These compounds have shown promise in reducing the microbial diseases linked to the development of drug tolerance and resistance. This paper offers a detailed review of some of the most vital and promising natural compounds and their derivatives against various human infectious microbial organisms. The inhibitory action of different natural antimicrobial compounds, and their possible mechanism of antimicrobial action against a range of pathogenic fungal and bacterial organisms, is provided. The review will be useful in refining current antimicrobial (antifungal and antibacterial) medicines as well as establishing new treatment strategies to tackle the rising number of human bacterial and fungal-associated infections. Elsevier 2022-09 2022-07-18 /pmc/articles/PMC9290337/ /pubmed/35874656 http://dx.doi.org/10.1016/j.sjbs.2022.103376 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Qadri, Hafsa Haseeb Shah, Abdul Mudasir Ahmad, Syed Alshehri, Bader Almilaibary, Abdullah Ahmad Mir, Manzoor Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title | Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title_full | Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title_fullStr | Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title_full_unstemmed | Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title_short | Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
title_sort | natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290337/ https://www.ncbi.nlm.nih.gov/pubmed/35874656 http://dx.doi.org/10.1016/j.sjbs.2022.103376 |
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