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Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India

BACKGROUND: Chronic opioid use affects biological functioning implicating the hematopoietic and immune system. It may alter various hematological parameters and inflammatory markers. This study aimed to assess the association of opioid dependence with the hematological parameters and inflammatory ma...

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Autores principales: Quraishi, Rizwana, Kathiresan, Preethy, Verma, Kamini, Rao, Ravindra, Jain, Raka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290418/
https://www.ncbi.nlm.nih.gov/pubmed/35859548
http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_751_21
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author Quraishi, Rizwana
Kathiresan, Preethy
Verma, Kamini
Rao, Ravindra
Jain, Raka
author_facet Quraishi, Rizwana
Kathiresan, Preethy
Verma, Kamini
Rao, Ravindra
Jain, Raka
author_sort Quraishi, Rizwana
collection PubMed
description BACKGROUND: Chronic opioid use affects biological functioning implicating the hematopoietic and immune system. It may alter various hematological parameters and inflammatory markers. This study aimed to assess the association of opioid dependence with the hematological parameters and inflammatory markers in the Indian population. METHODS: A retrospective chart review was done among opioid dependent (ODS) males and healthy controls (HC) who visited the center’s laboratory between Jan 2017 and Dec 2018 for hematological investigations. Clinical records reviewed for opioid use details like type, duration, and route of administration. The hematological profile presented as Mean or median. Mann–Whitney U test was used to compare the hematological parameters between the cases and controls. RESULTS: The study included 191 ODS patients and 123 controls. Among ODS patients, a significant decrease in the levels of hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin and an increase in RBC count and lymphocytes was observed when compared to controls. The inflammatory markers, Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio, were significantly lower among ODS. Longer duration of opioid use leads to increased NLR among ODS patients. Opioid use by injection did not alter any of the hematological parameters compared to non-injection drug use. CONCLUSION: Chronic opioid use has a significant effect on the hematopoietic cells. Opioid use for longer durations increases the inflammatory markers suggesting underlying infections.
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spelling pubmed-92904182022-07-19 Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India Quraishi, Rizwana Kathiresan, Preethy Verma, Kamini Rao, Ravindra Jain, Raka Indian J Psychiatry Original Article BACKGROUND: Chronic opioid use affects biological functioning implicating the hematopoietic and immune system. It may alter various hematological parameters and inflammatory markers. This study aimed to assess the association of opioid dependence with the hematological parameters and inflammatory markers in the Indian population. METHODS: A retrospective chart review was done among opioid dependent (ODS) males and healthy controls (HC) who visited the center’s laboratory between Jan 2017 and Dec 2018 for hematological investigations. Clinical records reviewed for opioid use details like type, duration, and route of administration. The hematological profile presented as Mean or median. Mann–Whitney U test was used to compare the hematological parameters between the cases and controls. RESULTS: The study included 191 ODS patients and 123 controls. Among ODS patients, a significant decrease in the levels of hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin and an increase in RBC count and lymphocytes was observed when compared to controls. The inflammatory markers, Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio, were significantly lower among ODS. Longer duration of opioid use leads to increased NLR among ODS patients. Opioid use by injection did not alter any of the hematological parameters compared to non-injection drug use. CONCLUSION: Chronic opioid use has a significant effect on the hematopoietic cells. Opioid use for longer durations increases the inflammatory markers suggesting underlying infections. Wolters Kluwer - Medknow 2022 2022-06-08 /pmc/articles/PMC9290418/ /pubmed/35859548 http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_751_21 Text en Copyright: © 2022 Indian Journal of Psychiatry https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Quraishi, Rizwana
Kathiresan, Preethy
Verma, Kamini
Rao, Ravindra
Jain, Raka
Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title_full Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title_fullStr Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title_full_unstemmed Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title_short Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India
title_sort effect of chronic opioid use on the hematological and inflammatory markers: a retrospective study from north india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290418/
https://www.ncbi.nlm.nih.gov/pubmed/35859548
http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_751_21
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