Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission

Because oral transmission of SARS-CoV-2 is 3–5 orders of magnitude higher than nasal transmission, we investigated debulking of oral viruses using viral trap proteins (CTB-ACE2, FRIL) expressed in plant cells, delivered through the chewing gum. In omicron nasopharyngeal (NP) samples, the microbubble...

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Detalles Bibliográficos
Autores principales: Daniell, Henry, Nair, Smruti K., Guan, Hancheng, Guo, Yuwei, Kulchar, Rachel J., Torres, Marcelo D.T., Shahed-Al-Mahmud, Md., Wakade, Geetanjali, Liu, Yo-Min, Marques, Andrew D., Graham-Wooten, Jevon, Zhou, Wan, Wang, Ping, Molugu, Sudheer K., de Araujo, William R., de la Fuente-Nunez, Cesar, Ma, Che, Short, William R., Tebas, Pablo, Margulies, Kenneth B., Bushman, Frederic D., Mante, Francis K., Ricciardi, Robert P., Collman, Ronald G., Wolff, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290430/
https://www.ncbi.nlm.nih.gov/pubmed/35953331
http://dx.doi.org/10.1016/j.biomaterials.2022.121671

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