Cargando…

Beta‐amyloid pore linked to controlled calcium influx into the cell: A new paradigm for Alzheimer's Disease

Despite tremendous worldwide efforts, clinical trials assessing Alzheimer's disease (AD)‐related therapeutics have been relentlessly unsuccessful. Hence, there is an urgent need to challenge old hypotheses with novel paradigms. An emerging concept is that the amyloid‐beta (Aβ) peptide, which wa...

Descripción completa

Detalles Bibliográficos
Autor principal:	Pannuzzo, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290490/ https://www.ncbi.nlm.nih.gov/pubmed/34051062 http://dx.doi.org/10.1002/alz.12373

Ejemplares similares

Amyloid pores in mitochondrial membranes
por: Vassallo, Neville
Publicado: (2021)

The tip of the iceberg? The underestimated potential of non-canonical beta-amyloids for Alzheimer’s disease
por: Busch, Lukas, et al.
Publicado: (2023)

Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores
por: Arbor, Sage C., et al.
Publicado: (2016)

Bayes analysis supports null hypothesis of anti‐amyloid beta therapy in Alzheimer's disease
por: Richard, Edo, et al.
Publicado: (2021)

Plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive Alzheimer’s disease
por: An, Seong Soo A., et al.
Publicado: (2023)

Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data
por: Di Scala, Coralie, et al.
Publicado: (2016)

Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease
por: Castillo, Willian O., et al.
Publicado: (2017)

Recent advancements toward non-invasive imaging of retinal amyloid-beta for early detection of Alzheimer’s disease
por: Wang, Liang, et al.
Publicado: (2022)

Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology
por: Ullah, Ghanim, et al.
Publicado: (2015)

Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
por: Bouillot, Stéphanie, et al.
Publicado: (2018)

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer’s disease prevention
por: Gopalakrishna, Rayudu, et al.
Publicado: (2023)

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells
por: Drews, Anna, et al.
Publicado: (2016)

Molecular identities of mitochondrial Ca(2+) influx mechanism: Updated passwords for accessing mitochondrial Ca(2+)-linked health and disease
por: O-Uchi, Jin, et al.
Publicado: (2012)

Phosphorylation of amyloid beta (Aβ) peptides – A trigger for formation of toxic aggregates in Alzheimer's disease
por: Kumar, Sathish, et al.
Publicado: (2011)

Finding chemopreventatives to reduce amyloid beta in yeast
por: Macreadie, Ian G., et al.
Publicado: (2016)

Defective autophagy and Alzheimer’s disease: is calcium the key?
por: Filadi, Riccardo, et al.
Publicado: (2019)

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation
por: Arbor, Sage
Publicado: (2017)

Reduced CSF Water Influx in Alzheimer’s Disease Supporting the β-Amyloid Clearance Hypothesis
por: Suzuki, Yuji, et al.
Publicado: (2015)

TDP-43 and amyloid precursor protein processing: implications for Alzheimer’s disease
por: Hicks, David A.
Publicado: (2020)

Anti-amyloid therapies for Alzheimer disease: finally, good news for patients
por: Ramanan, Vijay K., et al.
Publicado: (2023)

Suilysin-induced Platelet-Neutrophil Complexes Formation is Triggered by Pore Formation-dependent Calcium Influx
por: Zhang, Shengwei, et al.
Publicado: (2016)

Rift Valley Fever and a New Paradigm of Research and Development for Zoonotic Disease Control
por: Dar, Osman, et al.
Publicado: (2013)

Anti-amyloid: An antibody to cure Alzheimer’s or an attitude
por: Osborne, Olivia M., et al.
Publicado: (2023)

Increased intron retention is linked to Alzheimer’s disease
por: Ong, Chin-Tong, et al.
Publicado: (2019)

Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer’s disease
por: Igarashi, Hironaka, et al.
Publicado: (2014)

Clearance of amyloid‐beta with bispecific antibody constructs bound to erythrocytes
por: Taylor, Ronald P., et al.
Publicado: (2020)

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression
por: Kwakowsky, Andrea, et al.
Publicado: (2020)

A crate of Pandora: do amyloids from bacteria promote Alzheimer’s disease?
por: Nguyen, Vu Thu Thuy, et al.
Publicado: (2020)

Calcium handling: a strategy to fight neurodegeneration in Alzheimer’s disease
por: La Barbera, Livia, et al.
Publicado: (2023)

Amyloid beta is an early responder cytokine and immunopeptide of the innate immune system
por: Weaver, Donald F.
Publicado: (2020)

Consequences of redefining Alzheimer's disease in terms of amyloid burden without regard to cognitive decline
por: Robinson, Stephen R., et al.
Publicado: (2018)

Reversing Alzheimer's disease dementia with clemastine, fingolimod, or rolipram, plus anti‐amyloid therapy
por: Fessel, Jeffrey
Publicado: (2022)

Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-β story
por: Imbimbo, Bruno P., et al.
Publicado: (2022)

Misfolded amyloid-β strains and their potential roles in the clinical and pathological variability of Alzheimer’s disease
por: Kelley, Sara, et al.
Publicado: (2022)

Amyloid Beta in Aging and Alzheimer’s Disease
por: Sehar, Ujala, et al.
Publicado: (2022)

Role of presynaptic calcium stores for neural network dysfunction in Alzheimer's disease
por: Lerdkrai, Chommanad, et al.
Publicado: (2018)

Targeting calcium signaling in Alzheimer’s disease: challenges and promising therapeutic avenues
por: Song, LinLin, et al.
Publicado: (2023)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

Simulation-a new educational paradigm?
por: Konia, Mojca, et al.
Publicado: (2013)

Disease-First: A New Paradigm for Environmental Health Science Research
por: Wilson, Samuel H., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_n4aei0aq4rdbsckjgdt0dts77k