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Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study

Detection of safety-threat signals during uncertainty is an important mechanism of developmental anxiety disorder (AD). Although extensive research has focused on the detection of uncertain threat signals in anxious individuals, relatively little attention has been given to the identification of saf...

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Detalles Bibliográficos
Autores principales: Jin, Yan, Zhang, Lei, Chen, Wei, Zheng, Xifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290664/
https://www.ncbi.nlm.nih.gov/pubmed/35860399
http://dx.doi.org/10.3389/fnhum.2022.896211
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author Jin, Yan
Zhang, Lei
Chen, Wei
Zheng, Xifu
author_facet Jin, Yan
Zhang, Lei
Chen, Wei
Zheng, Xifu
author_sort Jin, Yan
collection PubMed
description Detection of safety-threat signals during uncertainty is an important mechanism of developmental anxiety disorder (AD). Although extensive research has focused on the detection of uncertain threat signals in anxious individuals, relatively little attention has been given to the identification of safety signals during uncertainty, which is an important way to relieve anxiety in individuals with AD. To investigate this phenomenon, 16 subjects with high trait anxiety (HTA) and 16 with low trait anxiety (LTA) completed a modified cue-target task in certain and uncertain stimulus blocks. In the uncertain block, the cue was followed by a threat picture or safety picture in 20% of trials, respectively; in the certain block, the cue could be followed by a threat picture or a safety picture on 100% of trials. Behavioral responses and event-related potentials (ERPs) were recorded. The ERP results demonstrated that LTA participants exhibited larger P2 amplitudes in the detection of safety cues than of threat cues during the uncertain block, whereas HTA participants showed significant P2 amplitudes between the safety and threat cues during the certain block, impairing the detection of safety stimuli during uncertainty. However, all participants exhibited greater N2 amplitudes following threat cues in certainty or uncertainty conditions. These findings pertaining to the P2 amplitude suggested distinctive attentional biases between HTA and LTA individuals, whereas the N2 amplitude showed association learning in uncertain conditions, compensating for safety-threat detection in HTA individuals.
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spelling pubmed-92906642022-07-19 Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study Jin, Yan Zhang, Lei Chen, Wei Zheng, Xifu Front Hum Neurosci Neuroscience Detection of safety-threat signals during uncertainty is an important mechanism of developmental anxiety disorder (AD). Although extensive research has focused on the detection of uncertain threat signals in anxious individuals, relatively little attention has been given to the identification of safety signals during uncertainty, which is an important way to relieve anxiety in individuals with AD. To investigate this phenomenon, 16 subjects with high trait anxiety (HTA) and 16 with low trait anxiety (LTA) completed a modified cue-target task in certain and uncertain stimulus blocks. In the uncertain block, the cue was followed by a threat picture or safety picture in 20% of trials, respectively; in the certain block, the cue could be followed by a threat picture or a safety picture on 100% of trials. Behavioral responses and event-related potentials (ERPs) were recorded. The ERP results demonstrated that LTA participants exhibited larger P2 amplitudes in the detection of safety cues than of threat cues during the uncertain block, whereas HTA participants showed significant P2 amplitudes between the safety and threat cues during the certain block, impairing the detection of safety stimuli during uncertainty. However, all participants exhibited greater N2 amplitudes following threat cues in certainty or uncertainty conditions. These findings pertaining to the P2 amplitude suggested distinctive attentional biases between HTA and LTA individuals, whereas the N2 amplitude showed association learning in uncertain conditions, compensating for safety-threat detection in HTA individuals. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9290664/ /pubmed/35860399 http://dx.doi.org/10.3389/fnhum.2022.896211 Text en Copyright © 2022 Jin, Zhang, Chen and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jin, Yan
Zhang, Lei
Chen, Wei
Zheng, Xifu
Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title_full Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title_fullStr Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title_full_unstemmed Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title_short Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study
title_sort early safety discrimination under uncertainty in trait anxiety: an event-related potential study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290664/
https://www.ncbi.nlm.nih.gov/pubmed/35860399
http://dx.doi.org/10.3389/fnhum.2022.896211
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