TDM is dead. Long live TCI!

Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because of the precision of the approach and the ability to link TCI to principles of pharmacokinetics and pharmacodynamics t...

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Detalles Bibliográficos
Autores principales: Holford, Nick, Ma, Guangda, Metz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Pharmacometrics: Past, Present and Future ‐ Themed Issue Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290673/
https://www.ncbi.nlm.nih.gov/pubmed/32543717
http://dx.doi.org/10.1111/bcp.14434
Descripción
Sumario:Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because of the precision of the approach and the ability to link TCI to principles of pharmacokinetics and pharmacodynamics to predict the dose required by an individual (1). We examine the theory and clinical trial evidence supporting the benefits of TCI over TDM and conclude that in the digital age TDM should be abandoned and replaced by TCI.

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