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Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment

Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature to explore the association between migraine and depression. Genetic overl...

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Autores principales: Asif, Nailah, Patel, Apurva, Vedantam, Deepanjali, Poman, Devyani S, Motwani, Lakshya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290761/
https://www.ncbi.nlm.nih.gov/pubmed/35865445
http://dx.doi.org/10.7759/cureus.25998
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author Asif, Nailah
Patel, Apurva
Vedantam, Deepanjali
Poman, Devyani S
Motwani, Lakshya
author_facet Asif, Nailah
Patel, Apurva
Vedantam, Deepanjali
Poman, Devyani S
Motwani, Lakshya
author_sort Asif, Nailah
collection PubMed
description Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature to explore the association between migraine and depression. Genetic overlap of various gene segments was studied, and heritability patterns were explored. Shared mechanisms such as serotonergic dysfunction, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and hormonal effects were investigated, and commonalities like comorbidities, stress, and environmental factors were analyzed. Migraine with comorbid depression (MID) affects various aspects of life and its clinical impact on migraine disability, quality of life (QOL), progression, and medication overuse was investigated. We further inspected several types of research in order to provide options on various treatment modalities. Pharmacotherapy such as antidepressants and anti-Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies like fremanezumab were studied. Alternative treatment options such as onabotulinumtoxinA (OBTA) injections, cognitive behavioral therapy (CBT), and vagal nerve stimulations (VNS) were also appraised and the efficacies of each were compared.
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spelling pubmed-92907612022-07-20 Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment Asif, Nailah Patel, Apurva Vedantam, Deepanjali Poman, Devyani S Motwani, Lakshya Cureus Internal Medicine Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature to explore the association between migraine and depression. Genetic overlap of various gene segments was studied, and heritability patterns were explored. Shared mechanisms such as serotonergic dysfunction, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and hormonal effects were investigated, and commonalities like comorbidities, stress, and environmental factors were analyzed. Migraine with comorbid depression (MID) affects various aspects of life and its clinical impact on migraine disability, quality of life (QOL), progression, and medication overuse was investigated. We further inspected several types of research in order to provide options on various treatment modalities. Pharmacotherapy such as antidepressants and anti-Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies like fremanezumab were studied. Alternative treatment options such as onabotulinumtoxinA (OBTA) injections, cognitive behavioral therapy (CBT), and vagal nerve stimulations (VNS) were also appraised and the efficacies of each were compared. Cureus 2022-06-16 /pmc/articles/PMC9290761/ /pubmed/35865445 http://dx.doi.org/10.7759/cureus.25998 Text en Copyright © 2022, Asif et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Asif, Nailah
Patel, Apurva
Vedantam, Deepanjali
Poman, Devyani S
Motwani, Lakshya
Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title_full Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title_fullStr Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title_full_unstemmed Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title_short Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
title_sort migraine with comorbid depression: pathogenesis, clinical implications, and treatment
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290761/
https://www.ncbi.nlm.nih.gov/pubmed/35865445
http://dx.doi.org/10.7759/cureus.25998
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