Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma

Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD‐1/PD‐L1 pathway, possibly strengthening the rationale for...

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Autores principales: Ishii, Hiroki, Tsujikawa, Takahiro, Oishi, Naoki, Kinouchi, Arisa, Sakamoto, Kaname, Mitsuda, Junichi, Ogi, Hiroshi, Itoh, Kyoko, Kondo, Tetsuo, Hirano, Shigeru, Sakurai, Daiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290770/
https://www.ncbi.nlm.nih.gov/pubmed/35865779
http://dx.doi.org/10.1002/ccr3.6050
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author Ishii, Hiroki
Tsujikawa, Takahiro
Oishi, Naoki
Kinouchi, Arisa
Sakamoto, Kaname
Mitsuda, Junichi
Ogi, Hiroshi
Itoh, Kyoko
Kondo, Tetsuo
Hirano, Shigeru
Sakurai, Daiju
author_facet Ishii, Hiroki
Tsujikawa, Takahiro
Oishi, Naoki
Kinouchi, Arisa
Sakamoto, Kaname
Mitsuda, Junichi
Ogi, Hiroshi
Itoh, Kyoko
Kondo, Tetsuo
Hirano, Shigeru
Sakurai, Daiju
author_sort Ishii, Hiroki
collection PubMed
description Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD‐1/PD‐L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment.
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spelling pubmed-92907702022-07-20 Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma Ishii, Hiroki Tsujikawa, Takahiro Oishi, Naoki Kinouchi, Arisa Sakamoto, Kaname Mitsuda, Junichi Ogi, Hiroshi Itoh, Kyoko Kondo, Tetsuo Hirano, Shigeru Sakurai, Daiju Clin Case Rep Case Report Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD‐1/PD‐L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment. John Wiley and Sons Inc. 2022-07-18 /pmc/articles/PMC9290770/ /pubmed/35865779 http://dx.doi.org/10.1002/ccr3.6050 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Ishii, Hiroki
Tsujikawa, Takahiro
Oishi, Naoki
Kinouchi, Arisa
Sakamoto, Kaname
Mitsuda, Junichi
Ogi, Hiroshi
Itoh, Kyoko
Kondo, Tetsuo
Hirano, Shigeru
Sakurai, Daiju
Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title_full Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title_fullStr Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title_full_unstemmed Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title_short Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
title_sort genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290770/
https://www.ncbi.nlm.nih.gov/pubmed/35865779
http://dx.doi.org/10.1002/ccr3.6050
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