Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B‐cell receptor signaling in mice

Bruton′s tyrosine kinase (Btk) is a crucial signaling molecule in BCR signaling and a key regulator of B‐ cell differentiation and function. Btk inhibition has shown impressive clinical efficacy in various B‐cell malignancies. However, it remains unknown whether inhibition additionally induces chang...

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Detalles Bibliográficos
Autores principales: Rip, Jasper, de Bruijn, Marjolein J. W., Neys, Stefan F. H., Singh, Simar Pal, Willar, Jonas, van Hulst, Jennifer A. C., Hendriks, Rudi W., Corneth, Odilia B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Molecular immunology and signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291019/
https://www.ncbi.nlm.nih.gov/pubmed/34323286
http://dx.doi.org/10.1002/eji.202048968

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