Advances in Treatment of Progressive Multifocal Leukoencephalopathy

Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS. However, when this restoration cannot be read...

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Autores principales: Bernard‐Valnet, Raphaël, Koralnik, Igor J., Du Pasquier, Renaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291129/
https://www.ncbi.nlm.nih.gov/pubmed/34405435
http://dx.doi.org/10.1002/ana.26198
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author Bernard‐Valnet, Raphaël
Koralnik, Igor J.
Du Pasquier, Renaud
author_facet Bernard‐Valnet, Raphaël
Koralnik, Igor J.
Du Pasquier, Renaud
author_sort Bernard‐Valnet, Raphaël
collection PubMed
description Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS. However, when this restoration cannot be readily achieved, PML has a grim prognosis. Innovative strategies have shown promise in promoting anti‐JCV immune responses, and include T‐cell adoptive transfer or immune checkpoint inhibitor therapies. Conversely, management of immune reconstitution inflammatory syndrome, particularly in iatrogenic PML, remains a major challenge. In this paper, we review recent development in the treatment of PML. ANN NEUROL 2021;90:865–873
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spelling pubmed-92911292022-07-20 Advances in Treatment of Progressive Multifocal Leukoencephalopathy Bernard‐Valnet, Raphaël Koralnik, Igor J. Du Pasquier, Renaud Ann Neurol Review Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS. However, when this restoration cannot be readily achieved, PML has a grim prognosis. Innovative strategies have shown promise in promoting anti‐JCV immune responses, and include T‐cell adoptive transfer or immune checkpoint inhibitor therapies. Conversely, management of immune reconstitution inflammatory syndrome, particularly in iatrogenic PML, remains a major challenge. In this paper, we review recent development in the treatment of PML. ANN NEUROL 2021;90:865–873 John Wiley & Sons, Inc. 2021-09-07 2021-12 /pmc/articles/PMC9291129/ /pubmed/34405435 http://dx.doi.org/10.1002/ana.26198 Text en © 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review
Bernard‐Valnet, Raphaël
Koralnik, Igor J.
Du Pasquier, Renaud
Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title_full Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title_fullStr Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title_full_unstemmed Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title_short Advances in Treatment of Progressive Multifocal Leukoencephalopathy
title_sort advances in treatment of progressive multifocal leukoencephalopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291129/
https://www.ncbi.nlm.nih.gov/pubmed/34405435
http://dx.doi.org/10.1002/ana.26198
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