Cargando…

Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life

Women reliant on mostly rice‐based diets can have inadequate thiamine intake, placing breastfed infants at risk of thiamine deficiency and, in turn, physical and cognitive impairments. We investigated the impact of maternal thiamine supplementation doses on infants’ cognitive, motor, and language de...

Descripción completa

Detalles Bibliográficos
Autores principales: Measelle, Jeffrey R., Baldwin, Dare A., Gallant, Jelisa, Chan, Kathleen, Green, Tim J., Wieringa, Frank T., Borath, Mam, Prak, Sophonneary, Hampel, Daniela, Shahab‐Ferdows, Setareh, Allen, Lindsay H., Kroeun, Hou, Whitfield, Kyly C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291201/
https://www.ncbi.nlm.nih.gov/pubmed/34101212
http://dx.doi.org/10.1111/nyas.14610
_version_ 1784749089914617856
author Measelle, Jeffrey R.
Baldwin, Dare A.
Gallant, Jelisa
Chan, Kathleen
Green, Tim J.
Wieringa, Frank T.
Borath, Mam
Prak, Sophonneary
Hampel, Daniela
Shahab‐Ferdows, Setareh
Allen, Lindsay H.
Kroeun, Hou
Whitfield, Kyly C.
author_facet Measelle, Jeffrey R.
Baldwin, Dare A.
Gallant, Jelisa
Chan, Kathleen
Green, Tim J.
Wieringa, Frank T.
Borath, Mam
Prak, Sophonneary
Hampel, Daniela
Shahab‐Ferdows, Setareh
Allen, Lindsay H.
Kroeun, Hou
Whitfield, Kyly C.
author_sort Measelle, Jeffrey R.
collection PubMed
description Women reliant on mostly rice‐based diets can have inadequate thiamine intake, placing breastfed infants at risk of thiamine deficiency and, in turn, physical and cognitive impairments. We investigated the impact of maternal thiamine supplementation doses on infants’ cognitive, motor, and language development across the first year. In this double‐blind, four‐parallel‐arm, randomized controlled trial, healthy mothers of exclusively breastfed newborn infants were recruited in Kampong Thom, Cambodia. At 2 weeks postnatal, women (n = 335) were randomized to one of four treatment groups to consume one capsule/day with varying amounts of thiamine for 22 weeks: 0, 1.2, 2.4, and 10 mg. At 2, 12, 24, and 52 weeks of age, infants were assessed with the Mullen Scales of Early Learning (MSEL) and the Caregiver Reported Early Development Instrument (CREDI). Multiple regression and mixed effects modeling suggest that by 6 months of age, the highest maternal thiamine dose (10 mg/day) held significant benefits for infants’ language development, but generally not for motor or visual reception development. Despite having achieved standardized scores on the MSEL that approximated U.S. norms by 6 months, infants showed a significant drop relative to these norms in both language domains following trial completion, indicating that nutritional interventions beyond 6 months may be necessary.
format Online
Article
Text
id pubmed-9291201
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-92912012022-07-20 Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life Measelle, Jeffrey R. Baldwin, Dare A. Gallant, Jelisa Chan, Kathleen Green, Tim J. Wieringa, Frank T. Borath, Mam Prak, Sophonneary Hampel, Daniela Shahab‐Ferdows, Setareh Allen, Lindsay H. Kroeun, Hou Whitfield, Kyly C. Ann N Y Acad Sci Original Articles Women reliant on mostly rice‐based diets can have inadequate thiamine intake, placing breastfed infants at risk of thiamine deficiency and, in turn, physical and cognitive impairments. We investigated the impact of maternal thiamine supplementation doses on infants’ cognitive, motor, and language development across the first year. In this double‐blind, four‐parallel‐arm, randomized controlled trial, healthy mothers of exclusively breastfed newborn infants were recruited in Kampong Thom, Cambodia. At 2 weeks postnatal, women (n = 335) were randomized to one of four treatment groups to consume one capsule/day with varying amounts of thiamine for 22 weeks: 0, 1.2, 2.4, and 10 mg. At 2, 12, 24, and 52 weeks of age, infants were assessed with the Mullen Scales of Early Learning (MSEL) and the Caregiver Reported Early Development Instrument (CREDI). Multiple regression and mixed effects modeling suggest that by 6 months of age, the highest maternal thiamine dose (10 mg/day) held significant benefits for infants’ language development, but generally not for motor or visual reception development. Despite having achieved standardized scores on the MSEL that approximated U.S. norms by 6 months, infants showed a significant drop relative to these norms in both language domains following trial completion, indicating that nutritional interventions beyond 6 months may be necessary. John Wiley and Sons Inc. 2021-06-07 2021-08 /pmc/articles/PMC9291201/ /pubmed/34101212 http://dx.doi.org/10.1111/nyas.14610 Text en © 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Measelle, Jeffrey R.
Baldwin, Dare A.
Gallant, Jelisa
Chan, Kathleen
Green, Tim J.
Wieringa, Frank T.
Borath, Mam
Prak, Sophonneary
Hampel, Daniela
Shahab‐Ferdows, Setareh
Allen, Lindsay H.
Kroeun, Hou
Whitfield, Kyly C.
Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title_full Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title_fullStr Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title_full_unstemmed Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title_short Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
title_sort thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291201/
https://www.ncbi.nlm.nih.gov/pubmed/34101212
http://dx.doi.org/10.1111/nyas.14610
work_keys_str_mv AT measellejeffreyr thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT baldwindarea thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT gallantjelisa thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT chankathleen thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT greentimj thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT wieringafrankt thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT borathmam thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT praksophonneary thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT hampeldaniela thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT shahabferdowssetareh thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT allenlindsayh thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT kroeunhou thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife
AT whitfieldkylyc thiaminesupplementationholdsneurocognitivebenefitsforbreastfedinfantsduringthefirstyearoflife