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FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design
INTRODUCTION: The incidence of Frontotemporal Lobar Degeneration (FTLD)–related disorders and their characteristics are not well known. The “FRONTotemporal dementia Incidence European Research Study” (FRONTIERS) is designed to fill this gap. METHODS: FRONTIERS is a European prospective, observationa...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291221/ https://www.ncbi.nlm.nih.gov/pubmed/34338439 http://dx.doi.org/10.1002/alz.12414 |
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author | Borroni, Barbara Graff, Caroline Hardiman, Orla Ludolph, Albert C. Moreno, Fermin Otto, Markus Piccininni, Marco Remes, Anne M Rowe, James B Seelaar, Harro Stefanova, Elka Traykov, Latchezar Logroscino, Giancarlo |
author_facet | Borroni, Barbara Graff, Caroline Hardiman, Orla Ludolph, Albert C. Moreno, Fermin Otto, Markus Piccininni, Marco Remes, Anne M Rowe, James B Seelaar, Harro Stefanova, Elka Traykov, Latchezar Logroscino, Giancarlo |
author_sort | Borroni, Barbara |
collection | PubMed |
description | INTRODUCTION: The incidence of Frontotemporal Lobar Degeneration (FTLD)–related disorders and their characteristics are not well known. The “FRONTotemporal dementia Incidence European Research Study” (FRONTIERS) is designed to fill this gap. METHODS: FRONTIERS is a European prospective, observational population study based on multinational registries. FRONTIERS comprises 11 tertiary referral centers across Europe with long‐lasting experience in FTLD‐related disorders and comprehensive regional referral networks, enabling incidence estimation over well‐defined geographical areas. ENDPOINTS: The primary endpoints are (1) the incidence of FTLD‐related disorders across Europe; (2) geographic trends of FTLD‐related disorders; (3) the distribution of FTLD phenotypes in different populations and ethnicities in Europe; (4) inheritance of FTLD‐related disorders, including the frequencies of monogenic FTLD as compared to overall disease burden; and (5) implementation of data banking for clinical and biological material. EXPECTED IMPACTS: FRONTIERS will improve the understanding of FTLD‐related disorders and their epidemiology, promoting appropriate public health service policies and treatment strategies. |
format | Online Article Text |
id | pubmed-9291221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92912212022-07-20 FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design Borroni, Barbara Graff, Caroline Hardiman, Orla Ludolph, Albert C. Moreno, Fermin Otto, Markus Piccininni, Marco Remes, Anne M Rowe, James B Seelaar, Harro Stefanova, Elka Traykov, Latchezar Logroscino, Giancarlo Alzheimers Dement Review Articles INTRODUCTION: The incidence of Frontotemporal Lobar Degeneration (FTLD)–related disorders and their characteristics are not well known. The “FRONTotemporal dementia Incidence European Research Study” (FRONTIERS) is designed to fill this gap. METHODS: FRONTIERS is a European prospective, observational population study based on multinational registries. FRONTIERS comprises 11 tertiary referral centers across Europe with long‐lasting experience in FTLD‐related disorders and comprehensive regional referral networks, enabling incidence estimation over well‐defined geographical areas. ENDPOINTS: The primary endpoints are (1) the incidence of FTLD‐related disorders across Europe; (2) geographic trends of FTLD‐related disorders; (3) the distribution of FTLD phenotypes in different populations and ethnicities in Europe; (4) inheritance of FTLD‐related disorders, including the frequencies of monogenic FTLD as compared to overall disease burden; and (5) implementation of data banking for clinical and biological material. EXPECTED IMPACTS: FRONTIERS will improve the understanding of FTLD‐related disorders and their epidemiology, promoting appropriate public health service policies and treatment strategies. John Wiley and Sons Inc. 2021-08-02 2022-03 /pmc/articles/PMC9291221/ /pubmed/34338439 http://dx.doi.org/10.1002/alz.12414 Text en © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Borroni, Barbara Graff, Caroline Hardiman, Orla Ludolph, Albert C. Moreno, Fermin Otto, Markus Piccininni, Marco Remes, Anne M Rowe, James B Seelaar, Harro Stefanova, Elka Traykov, Latchezar Logroscino, Giancarlo FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title | FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title_full | FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title_fullStr | FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title_full_unstemmed | FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title_short | FRONTotemporal dementia Incidence European Research Study—FRONTIERS: Rationale and design |
title_sort | frontotemporal dementia incidence european research study—frontiers: rationale and design |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291221/ https://www.ncbi.nlm.nih.gov/pubmed/34338439 http://dx.doi.org/10.1002/alz.12414 |
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