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Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study

Prognostic factors for excellent response (ER) to initial therapy in patients with papillary thyroid cancer (PTC) have not been determined. In this study, we investigated the response to initial therapy in PTC patients and independent prognostic factors for ER in a prospective multicenter study in C...

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Autores principales: Dong, Wen-Wu, Zhang, Da-Lin, He, Liang, Shao, Liang, Wang, Zhi-Hong, Lv, Cheng-Zhou, Zhang, Ping, Huang, Tao, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291439/
https://www.ncbi.nlm.nih.gov/pubmed/35860552
http://dx.doi.org/10.3389/fonc.2022.840714
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author Dong, Wen-Wu
Zhang, Da-Lin
He, Liang
Shao, Liang
Wang, Zhi-Hong
Lv, Cheng-Zhou
Zhang, Ping
Huang, Tao
Zhang, Hao
author_facet Dong, Wen-Wu
Zhang, Da-Lin
He, Liang
Shao, Liang
Wang, Zhi-Hong
Lv, Cheng-Zhou
Zhang, Ping
Huang, Tao
Zhang, Hao
author_sort Dong, Wen-Wu
collection PubMed
description Prognostic factors for excellent response (ER) to initial therapy in patients with papillary thyroid cancer (PTC) have not been determined. In this study, we investigated the response to initial therapy in PTC patients and independent prognostic factors for ER in a prospective multicenter study in China. A total of 506 PTC patients from nine centers in China were enrolled in this study, all of whom underwent total or near total thyroidectomy with lymph node dissection and subsequent radioiodine therapy. Univariate and multivariable logistic regression analyses were carried out to determine the independent prognostic factors for ER. The optimal cutoff value of the number of metastatic lymph nodes for predicting ER was determined by the receiver operating characteristic curve. A total of 139 patients (27.5%) achieved ER after initial therapy. Extrathyroidal extension, the number of metastatic lymph nodes, and preablative-stimulated thyroglobulin (Ps-Tg) were independent risk factors for ER for the entire population. In a subgroup analysis, extrathyroidal extension and Ps-Tg were independent risk factors for ER in pathological N1a patients, while the number of metastatic lymph nodes and Ps-Tg were independent risk factors for ER in pathological N1b patients. The appropriate cutoff values of the number of metastatic lymph nodes in predicting ER were 5 and 13 for the entire population and pathological N1b PTC patients, respectively. PTC patients with more metastatic lymph nodes were more likely to fail to achieve ER. Extrathyroidal extension, the number of metastatic lymph nodes, and Ps-Tg were important prognostic factors for ER after initial therapy in PTC patients.
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spelling pubmed-92914392022-07-19 Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study Dong, Wen-Wu Zhang, Da-Lin He, Liang Shao, Liang Wang, Zhi-Hong Lv, Cheng-Zhou Zhang, Ping Huang, Tao Zhang, Hao Front Oncol Oncology Prognostic factors for excellent response (ER) to initial therapy in patients with papillary thyroid cancer (PTC) have not been determined. In this study, we investigated the response to initial therapy in PTC patients and independent prognostic factors for ER in a prospective multicenter study in China. A total of 506 PTC patients from nine centers in China were enrolled in this study, all of whom underwent total or near total thyroidectomy with lymph node dissection and subsequent radioiodine therapy. Univariate and multivariable logistic regression analyses were carried out to determine the independent prognostic factors for ER. The optimal cutoff value of the number of metastatic lymph nodes for predicting ER was determined by the receiver operating characteristic curve. A total of 139 patients (27.5%) achieved ER after initial therapy. Extrathyroidal extension, the number of metastatic lymph nodes, and preablative-stimulated thyroglobulin (Ps-Tg) were independent risk factors for ER for the entire population. In a subgroup analysis, extrathyroidal extension and Ps-Tg were independent risk factors for ER in pathological N1a patients, while the number of metastatic lymph nodes and Ps-Tg were independent risk factors for ER in pathological N1b patients. The appropriate cutoff values of the number of metastatic lymph nodes in predicting ER were 5 and 13 for the entire population and pathological N1b PTC patients, respectively. PTC patients with more metastatic lymph nodes were more likely to fail to achieve ER. Extrathyroidal extension, the number of metastatic lymph nodes, and Ps-Tg were important prognostic factors for ER after initial therapy in PTC patients. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9291439/ /pubmed/35860552 http://dx.doi.org/10.3389/fonc.2022.840714 Text en Copyright © 2022 Dong, Zhang, He, Shao, Wang, Lv, Zhang, Huang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dong, Wen-Wu
Zhang, Da-Lin
He, Liang
Shao, Liang
Wang, Zhi-Hong
Lv, Cheng-Zhou
Zhang, Ping
Huang, Tao
Zhang, Hao
Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title_full Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title_fullStr Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title_full_unstemmed Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title_short Prognostic Factors for Excellent Response to Initial Therapy in Patients With Papillary Thyroid Cancer From a Prospective Multicenter Study
title_sort prognostic factors for excellent response to initial therapy in patients with papillary thyroid cancer from a prospective multicenter study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291439/
https://www.ncbi.nlm.nih.gov/pubmed/35860552
http://dx.doi.org/10.3389/fonc.2022.840714
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