Cargando…

Bridge Functionalisation of Bicyclo[1.1.1]pentane Derivatives

“Escaping from flatland”, by increasing the saturation level and three‐dimensionality of drug‐like compounds, can enhance their potency, selectivity and pharmacokinetic profile. One approach that has attracted considerable recent attention is the bioisosteric replacement of aromatic rings, internal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Joseph M., Measom, Nicholas D., Murphy, John A., Poole, Darren L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Minireviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291545/ https://www.ncbi.nlm.nih.gov/pubmed/34151501 http://dx.doi.org/10.1002/anie.202106352

Ejemplares similares

Conquering the Synthesis and Functionalization of Bicyclo[1.1.1]pentanes
por: Shire, Bethany R., et al.
Publicado: (2023)

Exceptional reactivity of the bridgehead amine on bicyclo[1.1.1]pentane
por: Lu, Yong, et al.
Publicado: (2023)

Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
por: Wong, Marie L. J., et al.
Publicado: (2021)

An Insight into Non‐Covalent Interactions on the Bicyclo[1.1.1]pentane Scaffold
por: Grover, Nitika, et al.
Publicado: (2020)

Synthesis of Sulfur-Substituted Bicyclo[1.1.1]pentanes by Iodo-Sulfenylation of [1.1.1]Propellane
por: Livesley, Sarah, et al.
Publicado: (2022)

Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen‐Substituted Bicyclo[1.1.1]pentanes
por: Livesley, Sarah, et al.
Publicado: (2021)

A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
por: Bychek, Roman, et al.
Publicado: (2022)

Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
por: Caputo, Dimitri F. J., et al.
Publicado: (2018)

Synthesis of All‐Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
por: Nugent, Jeremy, et al.
Publicado: (2020)

Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)
por: Ripenko, Vasyl, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues
por: Owen, Benjamin, et al.
Publicado: (2022)

Sodium Bicyclo[1.1.1]pentanesulfinate: A Bench‐Stable Precursor for Bicyclo[1.1.1]pentylsulfones and Bicyclo‐ [1.1.1]pentanesulfonamides
por: Bär, Robin M., et al.
Publicado: (2020)

Time-Resolved Fluorescence Anisotropy of Bicyclo[1.1.1]pentane/Tolane-Based Molecular Rods Included in Tris(o-phenylenedioxy)cyclotriphosphazene (TPP)
por: Cipolloni, Marco, et al.
Publicado: (2015)

One-Pot Synthesis of Difluorobicyclo[1.1.1]pentanes from α-Allyldiazoacetates
por: Sharland, Jack C., et al.
Publicado: (2023)

Functionalised N‐Heterocyclic Carbene Ligands in Bimetallic Architectures
por: Evans, Kieren J., et al.
Publicado: (2020)

Pyridinium tetrakis(1,1,1-trifluoropentane-2,4-dionato)dysprosate
por: Wang, Yan, et al.
Publicado: (2011)

The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines
por: Pang, Qiwen, et al.
Publicado: (2022)

Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates
por: Shelp, Russell A., et al.
Publicado: (2021)

A bridge to transcription by RNA polymerase
por: Kaplan, Craig D, et al.
Publicado: (2008)

5-Aminopentan-1-ol
por: Betz, Richard, et al.
Publicado: (2011)

Structure of triaquatris(1,1,1-trifluoro-4-oxopentan-2-olato)cerium(III) as a possible fluorescent compound
por: Koizumi, Atsuya, et al.
Publicado: (2018)

Bridging spinal cord injuries
por: Fawcett, James W
Publicado: (2008)

Bridging the gap with bacterial art
por: Frankel, Eve, et al.
Publicado: (2023)

(Cyclopentane-1,1-diyl)dimethanol
por: Betz, Richard, et al.
Publicado: (2009)

Diazaphospholene and Diazaarsolene Derived Homogeneous Catalysis
por: Ould, Darren M. C., et al.
Publicado: (2020)

Building bridges with astrocytes for spinal cord repair
por: Miller, Robert H
Publicado: (2006)

Wearable cardioverter defibrillator: Bridge or alternative to implantation?
por: Barraud, Jeremie, et al.
Publicado: (2017)

1-Ammonio-1-phosphonopentane-1-phosphonic acid
por: Bon, V. V., et al.
Publicado: (2008)

1-(1,3-Benzodioxol-5-yl)pentan-1-one
por: Wang, Xiao-Ming, et al.
Publicado: (2008)

Oxidative stress bridges the gut microbiota and the occurrence of frailty syndrome
por: Chen, Si-Yue, et al.
Publicado: (2022)

Bis[μ-pentane-2,4-dionato(1−)]bis{aqua[1,1,1,5,5,5-hexafluoropentane-2,4-dionato(1−)]cobalt(II)}
por: Hunter, Gerald O., et al.
Publicado: (2009)

1′-Ethylsulfanyl-1,1′-bicyclohexyl-2-one
por: Sharma, Lalit Kumar, et al.
Publicado: (2010)

Role of LKB1 in lung cancer development
por: Makowski, L, et al.
Publicado: (2008)

Spectroscopic and crystallographic characterization of two cathinone derivatives: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride and 1-(4-methylphenyl)-2-(ethylamino)pentan-1-one (4-MEAP) hydrochloride
por: Rojkiewicz, Marcin, et al.
Publicado: (2017)

ARF-BP1 as a potential therapeutic target
por: Chen, D, et al.
Publicado: (2006)

Ammonium dihydrogen (1-ammoniopentane-1,1-diyl)diphosphonate
por: Dudko, Anatolij, et al.
Publicado: (2009)

Mechanisms of HTLV-1 persistence and transformation
por: Boxus, M, et al.
Publicado: (2009)

Pentane-1,5-diammonium tetrachloridopalladate(II)
por: Maris, Thierry
Publicado: (2007)

1,3,5-Tri-p-tolylpentane-1,5-dione
por: Shen, You-Liang
Publicado: (2008)

1,3,5-Tri-p-tolylpentane-1,5-diol
por: Thiruvalluvar, A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_p770vu8noea53ufmub1l44q183