Direct, Late‐Stage Mono‐N‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites

A selective mono‐N‐arylation strategy of amidines under Chan‐Lam conditions is described. During the reaction optimization phase, the isolation of a mononuclear Cu(II) complex provided unique mechanistic insight into the operation of Chan‐Lam mono‐N‐arylation. The scope of the process is demonstrate...

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Detalles Bibliográficos
Autores principales: Robertson, Jack, Ungogo, Marzuq A., Aldfer, Mustafa M., Lemgruber, Leandro, McWhinnie, Fergus S., Bode, Bela E., Jones, Katherine L., Watson, Allan J. B., de Koning, Harry P., Burley, Glenn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291547/
https://www.ncbi.nlm.nih.gov/pubmed/34357687
http://dx.doi.org/10.1002/cmdc.202100509

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