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A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow

The ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high‐resolution liquid chromatography Orbitrap mass spectrometry to characterize the toxicity and ch...

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Autores principales: Chibwe, Leah, Parrott, Joanne L., Shires, Kallie, Khan, Hufsa, Clarence, Stacey, Lavalle, Christine, Sullivan, Cheryl, O'Brien, Anna M., De Silva, Amila O., Muir, Derek C.G., Rochman, Chelsea M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291566/
https://www.ncbi.nlm.nih.gov/pubmed/34125977
http://dx.doi.org/10.1002/etc.5140
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author Chibwe, Leah
Parrott, Joanne L.
Shires, Kallie
Khan, Hufsa
Clarence, Stacey
Lavalle, Christine
Sullivan, Cheryl
O'Brien, Anna M.
De Silva, Amila O.
Muir, Derek C.G.
Rochman, Chelsea M.
author_facet Chibwe, Leah
Parrott, Joanne L.
Shires, Kallie
Khan, Hufsa
Clarence, Stacey
Lavalle, Christine
Sullivan, Cheryl
O'Brien, Anna M.
De Silva, Amila O.
Muir, Derek C.G.
Rochman, Chelsea M.
author_sort Chibwe, Leah
collection PubMed
description The ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high‐resolution liquid chromatography Orbitrap mass spectrometry to characterize the toxicity and chemical mixture of organic chemicals associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1‐, 3‐, and 10‐d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10‐d leachates, and greater toxicity in unfiltered leachates. Redundancy analysis showed that several benzothiazoles and aryl‐amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2‐aminobenzothiazole, 2‐mercaptobenzothiazole, N,N′‐diphenylguanidine, and N,N′‐diphenylurea. However, many other chemicals characterized as unknowns are likely to also play a key role in the adverse effects observed. Our study provides insight into the types of chemicals likely to be important toxicological drivers in tire leachates, and improves our understanding of the ecotoxicological impacts of tire wear particles. Environ Toxicol Chem 2022;41:1144–1153. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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spelling pubmed-92915662022-07-20 A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow Chibwe, Leah Parrott, Joanne L. Shires, Kallie Khan, Hufsa Clarence, Stacey Lavalle, Christine Sullivan, Cheryl O'Brien, Anna M. De Silva, Amila O. Muir, Derek C.G. Rochman, Chelsea M. Environ Toxicol Chem Special Section The ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high‐resolution liquid chromatography Orbitrap mass spectrometry to characterize the toxicity and chemical mixture of organic chemicals associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1‐, 3‐, and 10‐d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10‐d leachates, and greater toxicity in unfiltered leachates. Redundancy analysis showed that several benzothiazoles and aryl‐amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2‐aminobenzothiazole, 2‐mercaptobenzothiazole, N,N′‐diphenylguanidine, and N,N′‐diphenylurea. However, many other chemicals characterized as unknowns are likely to also play a key role in the adverse effects observed. Our study provides insight into the types of chemicals likely to be important toxicological drivers in tire leachates, and improves our understanding of the ecotoxicological impacts of tire wear particles. Environ Toxicol Chem 2022;41:1144–1153. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. John Wiley and Sons Inc. 2021-08-02 2022-05 /pmc/articles/PMC9291566/ /pubmed/34125977 http://dx.doi.org/10.1002/etc.5140 Text en © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Special Section
Chibwe, Leah
Parrott, Joanne L.
Shires, Kallie
Khan, Hufsa
Clarence, Stacey
Lavalle, Christine
Sullivan, Cheryl
O'Brien, Anna M.
De Silva, Amila O.
Muir, Derek C.G.
Rochman, Chelsea M.
A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title_full A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title_fullStr A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title_full_unstemmed A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title_short A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
title_sort deep dive into the complex chemical mixture and toxicity of tire wear particle leachate in fathead minnow
topic Special Section
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291566/
https://www.ncbi.nlm.nih.gov/pubmed/34125977
http://dx.doi.org/10.1002/etc.5140
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