Electrophilic Aminating Agents in Total Synthesis

Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and t...

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Detalles Bibliográficos
Autores principales: O'Neil, Lauren G., Bower, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291613/
https://www.ncbi.nlm.nih.gov/pubmed/33942955
http://dx.doi.org/10.1002/anie.202102864
Descripción
Sumario:Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and these underpin a range of powerful C−N bond‐forming processes. In this Review, we highlight the strategic use of electrophilic aminating agents in total synthesis.

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