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Electrophilic Aminating Agents in Total Synthesis
Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291613/ https://www.ncbi.nlm.nih.gov/pubmed/33942955 http://dx.doi.org/10.1002/anie.202102864 |
| _version_ | 1784749177130975232 |
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| author | O'Neil, Lauren G. Bower, John F. |
| author_facet | O'Neil, Lauren G. Bower, John F. |
| author_sort | O'Neil, Lauren G. |
| collection | PubMed |
| description | Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and these underpin a range of powerful C−N bond‐forming processes. In this Review, we highlight the strategic use of electrophilic aminating agents in total synthesis. |
| format | Online Article Text |
| id | pubmed-9291613 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92916132022-07-20 Electrophilic Aminating Agents in Total Synthesis O'Neil, Lauren G. Bower, John F. Angew Chem Int Ed Engl Reviews Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and these underpin a range of powerful C−N bond‐forming processes. In this Review, we highlight the strategic use of electrophilic aminating agents in total synthesis. John Wiley and Sons Inc. 2021-08-06 2021-12-01 /pmc/articles/PMC9291613/ /pubmed/33942955 http://dx.doi.org/10.1002/anie.202102864 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Reviews O'Neil, Lauren G. Bower, John F. Electrophilic Aminating Agents in Total Synthesis |
| title | Electrophilic Aminating Agents in Total Synthesis |
| title_full | Electrophilic Aminating Agents in Total Synthesis |
| title_fullStr | Electrophilic Aminating Agents in Total Synthesis |
| title_full_unstemmed | Electrophilic Aminating Agents in Total Synthesis |
| title_short | Electrophilic Aminating Agents in Total Synthesis |
| title_sort | electrophilic aminating agents in total synthesis |
| topic | Reviews |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291613/ https://www.ncbi.nlm.nih.gov/pubmed/33942955 http://dx.doi.org/10.1002/anie.202102864 |
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