Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH‐ASBMR SABRE Project

The surrogate threshold effect (STE) is defined as the minimum treatment effect on a surrogate that is reliably predictive of a treatment effect on the clinical outcome. It provides a framework for implementing a clinical trial with a surrogate endpoint. The aim of this study was to update our previ...

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Detalles Bibliográficos
Autores principales: Eastell, Richard, Vittinghoff, Eric, Lui, Li‐Yung, McCulloch, Charles E., Pavo, Imre, Chines, Arkadi, Khosla, Sundeep, Cauley, Jane A., Mitlak, Bruce, Bauer, Douglas C., Bouxsein, Mary, Black, Dennis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291617/
https://www.ncbi.nlm.nih.gov/pubmed/34490915
http://dx.doi.org/10.1002/jbmr.4433

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