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Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer

A series of 1,2,3-triazole analogues as novel fat mass and obesity-associated protein (FTO) inhibitors were synthesised in this study. Among all 1,2,3-triazoles, compound C6 exhibited the most robust inhibition of FTO with an IC(50) value of 780 nM. It displayed the potent antiproliferative activity...

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Detalles Bibliográficos
Autores principales:	Qin, Bo, Bai, Qian, Yan, Dan, Yin, Fanxiang, Zhu, Zhu, Xia, Chaoyuan, Yang, Yang, Zhao, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291647/ https://www.ncbi.nlm.nih.gov/pubmed/35833378 http://dx.doi.org/10.1080/14756366.2022.2098954

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