Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors

Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In the discovery of novel HDAC inhibitors with anticancer potency, the 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled as a cap group into the structure of HDAC inhibitor...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Chen, Yiming, Li, Fahui, Zhang, Lihui, Feng, Jinhong, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291665/
https://www.ncbi.nlm.nih.gov/pubmed/35833370
http://dx.doi.org/10.1080/14756366.2022.2097446

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