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Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis

The incidence of uterine corpus cancer has been increasing globally due to increase in obesity. However, a detailed analysis of long‐term epidemiological trends of corpus cancer in Japan, where obesity is relatively minimal, has not been conducted. In this retrospective, population‐based study using...

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Autores principales: Yagi, Asami, Ueda, Yutaka, Ikeda, Sayaka, Miyoshi, Ai, Nakagawa, Satoshi, Hiramatsu, Kosuke, Kobayashi, Eiji, Kimura, Toshihiro, Ito, Yuri, Nakayama, Tomio, Nakata, Kayo, Morishima, Toshitaka, Miyashiro, Isao, Kimura, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291773/
https://www.ncbi.nlm.nih.gov/pubmed/34494658
http://dx.doi.org/10.1002/ijc.33799
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author Yagi, Asami
Ueda, Yutaka
Ikeda, Sayaka
Miyoshi, Ai
Nakagawa, Satoshi
Hiramatsu, Kosuke
Kobayashi, Eiji
Kimura, Toshihiro
Ito, Yuri
Nakayama, Tomio
Nakata, Kayo
Morishima, Toshitaka
Miyashiro, Isao
Kimura, Tadashi
author_facet Yagi, Asami
Ueda, Yutaka
Ikeda, Sayaka
Miyoshi, Ai
Nakagawa, Satoshi
Hiramatsu, Kosuke
Kobayashi, Eiji
Kimura, Toshihiro
Ito, Yuri
Nakayama, Tomio
Nakata, Kayo
Morishima, Toshitaka
Miyashiro, Isao
Kimura, Tadashi
author_sort Yagi, Asami
collection PubMed
description The incidence of uterine corpus cancer has been increasing globally due to increase in obesity. However, a detailed analysis of long‐term epidemiological trends of corpus cancer in Japan, where obesity is relatively minimal, has not been conducted. In this retrospective, population‐based study using the Osaka Cancer Registry, we analyzed 15 255 cases of corpus neoplasia registered between 1977 and 2016. We determined the age‐standardized incidence, mortality, relative survival and conditional survival rates, and the treatment trends for corpus cancer over the last 40 years in Japan. The age‐standardized incidence rate of corpus neoplasia increased sharply in 2000‐2011 (APC = 9.9, 95% CI: 8.4‐11.3), whereas the mortality rate trended to a much more modest increase (APC = 3.3, 95% CI: 2.7‐3.8). Compared to 1977‐2000, 10‐year survival rates for post‐2000 cases of localized and regional corpus cancers significantly improved (from 87.7% [95% CI: 85.8‐89.4] to 94.2% [95% CI: 92.7‐95.7] and from 47.5% [95% CI: 43.3‐51.6] to 64.4% [95% CI: 61.0‐67.6], respectively). This was largely associated with the significant increase in the percentage of localized and regional patients who received chemotherapy instead of radiation as an adjuvant therapy combined to surgery (P < .001 for both). We found that each histological type (endometrioid carcinoma, serous carcinoma, clear cell carcinoma and carcinosarcoma) has different characteristics of trend of age‐standardized incidence rate, relative survival and distribution of extent of disease. In endometrioid carcinoma, the age‐standardized incidence rate increased consistently after 1990, but the rate of increase was decreasing after 1997.
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spelling pubmed-92917732022-07-20 Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis Yagi, Asami Ueda, Yutaka Ikeda, Sayaka Miyoshi, Ai Nakagawa, Satoshi Hiramatsu, Kosuke Kobayashi, Eiji Kimura, Toshihiro Ito, Yuri Nakayama, Tomio Nakata, Kayo Morishima, Toshitaka Miyashiro, Isao Kimura, Tadashi Int J Cancer Cancer Epidemiology The incidence of uterine corpus cancer has been increasing globally due to increase in obesity. However, a detailed analysis of long‐term epidemiological trends of corpus cancer in Japan, where obesity is relatively minimal, has not been conducted. In this retrospective, population‐based study using the Osaka Cancer Registry, we analyzed 15 255 cases of corpus neoplasia registered between 1977 and 2016. We determined the age‐standardized incidence, mortality, relative survival and conditional survival rates, and the treatment trends for corpus cancer over the last 40 years in Japan. The age‐standardized incidence rate of corpus neoplasia increased sharply in 2000‐2011 (APC = 9.9, 95% CI: 8.4‐11.3), whereas the mortality rate trended to a much more modest increase (APC = 3.3, 95% CI: 2.7‐3.8). Compared to 1977‐2000, 10‐year survival rates for post‐2000 cases of localized and regional corpus cancers significantly improved (from 87.7% [95% CI: 85.8‐89.4] to 94.2% [95% CI: 92.7‐95.7] and from 47.5% [95% CI: 43.3‐51.6] to 64.4% [95% CI: 61.0‐67.6], respectively). This was largely associated with the significant increase in the percentage of localized and regional patients who received chemotherapy instead of radiation as an adjuvant therapy combined to surgery (P < .001 for both). We found that each histological type (endometrioid carcinoma, serous carcinoma, clear cell carcinoma and carcinosarcoma) has different characteristics of trend of age‐standardized incidence rate, relative survival and distribution of extent of disease. In endometrioid carcinoma, the age‐standardized incidence rate increased consistently after 1990, but the rate of increase was decreasing after 1997. John Wiley & Sons, Inc. 2021-09-15 2022-01-15 /pmc/articles/PMC9291773/ /pubmed/34494658 http://dx.doi.org/10.1002/ijc.33799 Text en © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cancer Epidemiology
Yagi, Asami
Ueda, Yutaka
Ikeda, Sayaka
Miyoshi, Ai
Nakagawa, Satoshi
Hiramatsu, Kosuke
Kobayashi, Eiji
Kimura, Toshihiro
Ito, Yuri
Nakayama, Tomio
Nakata, Kayo
Morishima, Toshitaka
Miyashiro, Isao
Kimura, Tadashi
Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title_full Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title_fullStr Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title_full_unstemmed Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title_short Improved long‐term survival of corpus cancer in Japan: A 40‐year population‐based analysis
title_sort improved long‐term survival of corpus cancer in japan: a 40‐year population‐based analysis
topic Cancer Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291773/
https://www.ncbi.nlm.nih.gov/pubmed/34494658
http://dx.doi.org/10.1002/ijc.33799
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