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Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke

Stroke is a major cause of vascular cognitive dysfunction, such as memory impairment. We aimed to explore the neural substrates underlying verbal memory impairment in subcortical stroke patients by the methods of voxel‐wise cerebral blood flow (CBF) and the functional covariance network (FCN). Sixty...

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Autores principales: Wang, Caihong, Miao, Peifang, Liu, Jingchun, Li, Zhen, Wei, Ying, Wang, Yingying, Zhang, Yong, Wang, Kaiyu, Cheng, Jingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291780/
https://www.ncbi.nlm.nih.gov/pubmed/33774813
http://dx.doi.org/10.1111/jnc.15359
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author Wang, Caihong
Miao, Peifang
Liu, Jingchun
Li, Zhen
Wei, Ying
Wang, Yingying
Zhang, Yong
Wang, Kaiyu
Cheng, Jingliang
author_facet Wang, Caihong
Miao, Peifang
Liu, Jingchun
Li, Zhen
Wei, Ying
Wang, Yingying
Zhang, Yong
Wang, Kaiyu
Cheng, Jingliang
author_sort Wang, Caihong
collection PubMed
description Stroke is a major cause of vascular cognitive dysfunction, such as memory impairment. We aimed to explore the neural substrates underlying verbal memory impairment in subcortical stroke patients by the methods of voxel‐wise cerebral blood flow (CBF) and the functional covariance network (FCN). Sixty patients with chronic subcortical stroke and 60 normal controls (NCs) were recruited into this study. We used a three‐dimensional pseudo‐continuous arterial spin‐labeling imaging to measure alterations in CBF and FCNs. We mapped the overall CBF alterations in a voxel‐wise manner and compared CBF measurements using a two‐sample t test. Correlations between CBF and verbal memory were also investigated. Subsequently, we constructed FCNs by calculating the correlation between specific regions and all other voxels of a whole brain, separately within the two groups. Thereafter, by comparing differences of the FCN patterns between the patient and NC groups, we investigated the connection alterations within the FCN maps. The stroke patients showed verbal short‐term memory (VSTM) deficits compared to NCs. The patients exhibited decreased CBF in the ipsilesional insula and ventral sensorimotor network, and increased CBF in contralesional frontal cortical and subcortical regions (putamen and thalamus). Meanwhile, the CBF in the ipsilesional insula was positively correlated, and the contralesional frontal cortical was negativity correlated, with VSTM scores. Moreover we found that stroke patients exhibited disordered connection within FCNs compared to NCs. The study suggests that the underlying imaging biomarker of VSTM impairment in patients with subcortical stroke was associated with disconnection of the frontal lobe network. [Image: see text]
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spelling pubmed-92917802022-07-20 Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke Wang, Caihong Miao, Peifang Liu, Jingchun Li, Zhen Wei, Ying Wang, Yingying Zhang, Yong Wang, Kaiyu Cheng, Jingliang J Neurochem ORIGINAL ARTICLES Stroke is a major cause of vascular cognitive dysfunction, such as memory impairment. We aimed to explore the neural substrates underlying verbal memory impairment in subcortical stroke patients by the methods of voxel‐wise cerebral blood flow (CBF) and the functional covariance network (FCN). Sixty patients with chronic subcortical stroke and 60 normal controls (NCs) were recruited into this study. We used a three‐dimensional pseudo‐continuous arterial spin‐labeling imaging to measure alterations in CBF and FCNs. We mapped the overall CBF alterations in a voxel‐wise manner and compared CBF measurements using a two‐sample t test. Correlations between CBF and verbal memory were also investigated. Subsequently, we constructed FCNs by calculating the correlation between specific regions and all other voxels of a whole brain, separately within the two groups. Thereafter, by comparing differences of the FCN patterns between the patient and NC groups, we investigated the connection alterations within the FCN maps. The stroke patients showed verbal short‐term memory (VSTM) deficits compared to NCs. The patients exhibited decreased CBF in the ipsilesional insula and ventral sensorimotor network, and increased CBF in contralesional frontal cortical and subcortical regions (putamen and thalamus). Meanwhile, the CBF in the ipsilesional insula was positively correlated, and the contralesional frontal cortical was negativity correlated, with VSTM scores. Moreover we found that stroke patients exhibited disordered connection within FCNs compared to NCs. The study suggests that the underlying imaging biomarker of VSTM impairment in patients with subcortical stroke was associated with disconnection of the frontal lobe network. [Image: see text] John Wiley and Sons Inc. 2021-08-17 2021-10 /pmc/articles/PMC9291780/ /pubmed/33774813 http://dx.doi.org/10.1111/jnc.15359 Text en © 2021 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle ORIGINAL ARTICLES
Wang, Caihong
Miao, Peifang
Liu, Jingchun
Li, Zhen
Wei, Ying
Wang, Yingying
Zhang, Yong
Wang, Kaiyu
Cheng, Jingliang
Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title_full Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title_fullStr Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title_full_unstemmed Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title_short Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
title_sort validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291780/
https://www.ncbi.nlm.nih.gov/pubmed/33774813
http://dx.doi.org/10.1111/jnc.15359
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