Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa (TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is anticipated that TKO pigs will be better donors for human xenotransplantation. However, previous studies on TKO pigs using old wor...

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Detalles Bibliográficos
Autores principales: Ma, David, Hirose, Takayuki, Lassiter, Grace, Sasaki, Hajime, Rosales, Ivy, Coe, Taylor M., Rickert, Charles G., Matheson, Rudy, Colvin, Robert B., Qin, Wenning, Kan, Yinan, Layer, Jacob V., Paragas, Violette B., Stiede, Kathryn, Hall, Katherine C., Youd, Michele E., Queiroz, Luis M., Westlin, William F., Curtis, Michael, Yang, Luhan, Markmann, James F., Kawai, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291868/
https://www.ncbi.nlm.nih.gov/pubmed/34331749
http://dx.doi.org/10.1111/ajt.16780

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