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Integration of clinical perspective into biomimetic bioreactor design for orthopedics
The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor de...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292211/ https://www.ncbi.nlm.nih.gov/pubmed/34510706 http://dx.doi.org/10.1002/jbm.b.34929 |
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author | Drapal, Victoria Gamble, Jordan M. Robinson, Jennifer L. Tamerler, Candan Arnold, Paul M. Friis, Elizabeth A. |
author_facet | Drapal, Victoria Gamble, Jordan M. Robinson, Jennifer L. Tamerler, Candan Arnold, Paul M. Friis, Elizabeth A. |
author_sort | Drapal, Victoria |
collection | PubMed |
description | The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor designs can effectively provide either mechanical, electrical, or chemical stimuli to the controlled environment, these systems lack the ability to combine all these stimuli simultaneously to better recapitulate the physiological environment. Introducing a dynamic and systematic combination of biomimetic stimuli bioreactor systems could tremendously enhance its clinical relevance in research. Thus, cues from different tissue responses should be studied collectively and included in the design of a biomimetic bioreactor platform. This review begins by providing a summary on the progression of bioreactors from simple to complex designs, focusing on the major advances in bioreactor technology and the approaches employed to better simulate in vivo conditions. The current state of bioreactors in terms of their clinical relevance is also analyzed. Finally, this review provides a comprehensive overview of individual biophysical stimuli and their role in establishing a biomimetic microenvironment for tissue engineering. To date, the most advanced bioreactor designs only incorporate one or two stimuli. Thus, the cell response measured is likely unrelated to the actual clinical performance. Integrating clinically relevant stimuli in bioreactor designs to study cell response can further advance the understanding of physical phenomenon naturally occurring in the body. In the future, the clinically informed biomimetic bioreactor could yield more efficiently translatable results for improved patient care. |
format | Online Article Text |
id | pubmed-9292211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92922112022-07-20 Integration of clinical perspective into biomimetic bioreactor design for orthopedics Drapal, Victoria Gamble, Jordan M. Robinson, Jennifer L. Tamerler, Candan Arnold, Paul M. Friis, Elizabeth A. J Biomed Mater Res B Appl Biomater Review Articles The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor designs can effectively provide either mechanical, electrical, or chemical stimuli to the controlled environment, these systems lack the ability to combine all these stimuli simultaneously to better recapitulate the physiological environment. Introducing a dynamic and systematic combination of biomimetic stimuli bioreactor systems could tremendously enhance its clinical relevance in research. Thus, cues from different tissue responses should be studied collectively and included in the design of a biomimetic bioreactor platform. This review begins by providing a summary on the progression of bioreactors from simple to complex designs, focusing on the major advances in bioreactor technology and the approaches employed to better simulate in vivo conditions. The current state of bioreactors in terms of their clinical relevance is also analyzed. Finally, this review provides a comprehensive overview of individual biophysical stimuli and their role in establishing a biomimetic microenvironment for tissue engineering. To date, the most advanced bioreactor designs only incorporate one or two stimuli. Thus, the cell response measured is likely unrelated to the actual clinical performance. Integrating clinically relevant stimuli in bioreactor designs to study cell response can further advance the understanding of physical phenomenon naturally occurring in the body. In the future, the clinically informed biomimetic bioreactor could yield more efficiently translatable results for improved patient care. John Wiley & Sons, Inc. 2021-09-12 2022-02 /pmc/articles/PMC9292211/ /pubmed/34510706 http://dx.doi.org/10.1002/jbm.b.34929 Text en © 2021 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Drapal, Victoria Gamble, Jordan M. Robinson, Jennifer L. Tamerler, Candan Arnold, Paul M. Friis, Elizabeth A. Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title | Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title_full | Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title_fullStr | Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title_full_unstemmed | Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title_short | Integration of clinical perspective into biomimetic bioreactor design for orthopedics |
title_sort | integration of clinical perspective into biomimetic bioreactor design for orthopedics |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292211/ https://www.ncbi.nlm.nih.gov/pubmed/34510706 http://dx.doi.org/10.1002/jbm.b.34929 |
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