Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk

BACKGROUND: The leucine‐rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg, rs76904798) with lower effect sizes that are associated with Parkinson's disease (PD) risk. OBJECTIVES: This study aimed to investigate...

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Detalles Bibliográficos
Autores principales: Lake, Julie, Reed, Xylena, Langston, Rebekah G., Nalls, Mike A., Gan‐Or, Ziv, Cookson, Mark R., Singleton, Andrew B., Blauwendraat, Cornelis, Leonard, Hampton L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292230/
https://www.ncbi.nlm.nih.gov/pubmed/34542912
http://dx.doi.org/10.1002/mds.28787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292230/
https://www.ncbi.nlm.nih.gov/pubmed/34542912
http://dx.doi.org/10.1002/mds.28787

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