Mutant B2M‐HLA‐E and B2M‐HLA‐G fusion proteins protects universal chimeric antigen receptor‐modified T cells from allogeneic NK cell‐mediated lysis

Recent studies have indicated the antitumor activity and reduced allogeneic response of universal chimeric antigen receptor‐modified T (UCAR T) cells lacking endogenous T cell receptors and beta‐2 microglobulin (B2M) generated using gene‐editing technologies. However, these cells are vulnerable to l...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yelei, Xu, Beilei, Wu, Zhiqiang, Bo, Jian, Tong, Chuan, Chen, Deyun, Wang, Jin, Wang, Haoyi, Wang, Yao, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Immunomodulation and immune therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292285/
https://www.ncbi.nlm.nih.gov/pubmed/34323289
http://dx.doi.org/10.1002/eji.202049107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292285/
https://www.ncbi.nlm.nih.gov/pubmed/34323289
http://dx.doi.org/10.1002/eji.202049107

Ejemplares similares