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Mutant B2M‐HLA‐E and B2M‐HLA‐G fusion proteins protects universal chimeric antigen receptor‐modified T cells from allogeneic NK cell‐mediated lysis

Recent studies have indicated the antitumor activity and reduced allogeneic response of universal chimeric antigen receptor‐modified T (UCAR T) cells lacking endogenous T cell receptors and beta‐2 microglobulin (B2M) generated using gene‐editing technologies. However, these cells are vulnerable to l...

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Detalles Bibliográficos
Autores principales:	Guo, Yelei, Xu, Beilei, Wu, Zhiqiang, Bo, Jian, Tong, Chuan, Chen, Deyun, Wang, Jin, Wang, Haoyi, Wang, Yao, Han, Weidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Immunomodulation and immune therapies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292285/ https://www.ncbi.nlm.nih.gov/pubmed/34323289 http://dx.doi.org/10.1002/eji.202049107

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