Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors

Herein we report a microscale parallel synthetic approach allowing for rapid access to libraries of N‐acylated aminotriazoles and screening of their inhibitory activity against factor XIIa (FXIIa) and thrombin, which are targets for antithrombotic drugs. This approach, in combination with post‐scree...

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Detalles Bibliográficos
Autores principales: Platte, Simon, Korff, Marvin, Imberg, Lukas, Balicioglu, Ilker, Erbacher, Catharina, Will, Jonas M., Daniliuc, Constantin G., Karst, Uwe, Kalinin, Dmitrii V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292294/
https://www.ncbi.nlm.nih.gov/pubmed/34278727
http://dx.doi.org/10.1002/cmdc.202100431

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