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A Dose‐Confirmation Phase 1 Study to Evaluate the Safety and Pharmacology of Glucarpidase in Healthy Volunteers

Glucarpidase rapidly decomposes methotrexate. A phase 1 study of glucarpidase in an open‐label, randomized parallel group was conducted to evaluate the safety, pharmacokinetics, and other pharmacologic effects in Japanese healthy volunteers without methotrexate treatment. A dose of 50 U/kg (n = 8) o...

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Detalles Bibliográficos
Autores principales:	Fukaya, Yutaka, Kimura, Toshimi, Yoshimura, Kenichi, Umemura, Kazuo, Kawamoto, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292509/ https://www.ncbi.nlm.nih.gov/pubmed/34435467 http://dx.doi.org/10.1002/cpdd.1010

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