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Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing

The stem cell niche is a specialized microenvironment for stem cells in an adult tissue. The niche provides cues for the maintenance and regulation of stem cell activities and thus presents a target for potential rejuvenating strategies. García‐Prat et al. found that in the heterogeneous population...

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Autores principales: Potapov, Ilya, García‐Prat, Laura, Ravichandran, Srikanth, Muñoz‐Cánoves, Pura, del Sol, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292515/
https://www.ncbi.nlm.nih.gov/pubmed/33752266
http://dx.doi.org/10.1111/febs.15832
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author Potapov, Ilya
García‐Prat, Laura
Ravichandran, Srikanth
Muñoz‐Cánoves, Pura
del Sol, Antonio
author_facet Potapov, Ilya
García‐Prat, Laura
Ravichandran, Srikanth
Muñoz‐Cánoves, Pura
del Sol, Antonio
author_sort Potapov, Ilya
collection PubMed
description The stem cell niche is a specialized microenvironment for stem cells in an adult tissue. The niche provides cues for the maintenance and regulation of stem cell activities and thus presents a target for potential rejuvenating strategies. García‐Prat et al. found that in the heterogeneous population of quiescent stem cells of skeletal muscles, a fraction of cells responsible for regeneration and having genuine ‘stemness’ properties deteriorates only in extremely old age. An essential tool used in this analysis of stem cell–niche interactions is the computational tool, NicheHotSpotter, which proved to be instrumental for identifying niche and cell signalling factors that contribute to the maintenance of the pool of genuine quiescent stem cells. NicheHotSpotter predicts candidate factors by analysing signalling interactome and gene regulatory network data in combination with expression profiles. The effect of the niche environment on stem cells is modelled as a mean field of niche cues that induce sustained activation or inhibition of signalling pathways. In this way, NicheHotSpotter has been successful in delineating novel strategies to enhance stemness, which may rejuvenate skeletal muscle cells at the extreme old age.
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spelling pubmed-92925152022-07-20 Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing Potapov, Ilya García‐Prat, Laura Ravichandran, Srikanth Muñoz‐Cánoves, Pura del Sol, Antonio FEBS J Emerging Methods And Technologies The stem cell niche is a specialized microenvironment for stem cells in an adult tissue. The niche provides cues for the maintenance and regulation of stem cell activities and thus presents a target for potential rejuvenating strategies. García‐Prat et al. found that in the heterogeneous population of quiescent stem cells of skeletal muscles, a fraction of cells responsible for regeneration and having genuine ‘stemness’ properties deteriorates only in extremely old age. An essential tool used in this analysis of stem cell–niche interactions is the computational tool, NicheHotSpotter, which proved to be instrumental for identifying niche and cell signalling factors that contribute to the maintenance of the pool of genuine quiescent stem cells. NicheHotSpotter predicts candidate factors by analysing signalling interactome and gene regulatory network data in combination with expression profiles. The effect of the niche environment on stem cells is modelled as a mean field of niche cues that induce sustained activation or inhibition of signalling pathways. In this way, NicheHotSpotter has been successful in delineating novel strategies to enhance stemness, which may rejuvenate skeletal muscle cells at the extreme old age. John Wiley and Sons Inc. 2021-05-14 2022-03 /pmc/articles/PMC9292515/ /pubmed/33752266 http://dx.doi.org/10.1111/febs.15832 Text en © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Emerging Methods And Technologies
Potapov, Ilya
García‐Prat, Laura
Ravichandran, Srikanth
Muñoz‐Cánoves, Pura
del Sol, Antonio
Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title_full Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title_fullStr Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title_full_unstemmed Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title_short Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
title_sort computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
topic Emerging Methods And Technologies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292515/
https://www.ncbi.nlm.nih.gov/pubmed/33752266
http://dx.doi.org/10.1111/febs.15832
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