Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge

We used mass cytometry to extensively characterize bronchoalveolar lavage macrophages before and two days after in vivo rhinovirus 16 infection in a heterogeneous population of healthy and asthma/COPD subjects. Multivariate partial least squares discriminant analysis revealed distinct clusters of al...

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Autores principales: de Groot, Linsey E. S., Brinkman, Paul, Sabogal Piñeros, Yanaika S., Priller, Josef, Hamann, Jörg, Böttcher, Chotima, Lutter, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292529/
https://www.ncbi.nlm.nih.gov/pubmed/34492126
http://dx.doi.org/10.1002/eji.202149222
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author de Groot, Linsey E. S.
Brinkman, Paul
Sabogal Piñeros, Yanaika S.
Priller, Josef
Hamann, Jörg
Böttcher, Chotima
Lutter, René
author_facet de Groot, Linsey E. S.
Brinkman, Paul
Sabogal Piñeros, Yanaika S.
Priller, Josef
Hamann, Jörg
Böttcher, Chotima
Lutter, René
author_sort de Groot, Linsey E. S.
collection PubMed
description We used mass cytometry to extensively characterize bronchoalveolar lavage macrophages before and two days after in vivo rhinovirus 16 infection in a heterogeneous population of healthy and asthma/COPD subjects. Multivariate partial least squares discriminant analysis revealed distinct clusters of alveolar macrophages before versus after the virus, suggesting changes in overall phenotype. [Image: see text]
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spelling pubmed-92925292022-07-20 Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge de Groot, Linsey E. S. Brinkman, Paul Sabogal Piñeros, Yanaika S. Priller, Josef Hamann, Jörg Böttcher, Chotima Lutter, René Eur J Immunol Letters to the Editor We used mass cytometry to extensively characterize bronchoalveolar lavage macrophages before and two days after in vivo rhinovirus 16 infection in a heterogeneous population of healthy and asthma/COPD subjects. Multivariate partial least squares discriminant analysis revealed distinct clusters of alveolar macrophages before versus after the virus, suggesting changes in overall phenotype. [Image: see text] John Wiley and Sons Inc. 2021-09-16 2021-11 /pmc/articles/PMC9292529/ /pubmed/34492126 http://dx.doi.org/10.1002/eji.202149222 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Letters to the Editor
de Groot, Linsey E. S.
Brinkman, Paul
Sabogal Piñeros, Yanaika S.
Priller, Josef
Hamann, Jörg
Böttcher, Chotima
Lutter, René
Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title_full Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title_fullStr Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title_full_unstemmed Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title_short Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
title_sort phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292529/
https://www.ncbi.nlm.nih.gov/pubmed/34492126
http://dx.doi.org/10.1002/eji.202149222
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